Novel endoscopic papillectomy for reducing postoperative adverse events (with videos)

Table 1 Baseline characteristics of the two groups

		N group (n = 23)	C group (n = 53)	P value
Age		59.30 ± 9.55	58.06 ± 13.09	0.682
Sex		9:14	27:26	0.343
Symptomatic		13/23	32/53	0.753
Intra-operation	BD dilation	2/23	10/53	0.327
	Resection size (cm2)	3.668 ± 2.904	4.780 ± 6.536	0.582
Pathologic result	HGIN	8	20
	LGIN	3	8
	Non-GIN	10	16
	NT	1	1	0.703
Postoperative hospital stay (d)		10.35 ± 4.23	10.08 ± 3.60	0.783
Total cost (Yuan)		45243.75 ± 11443.68	58158.77 ± 79290.51	0.473

N group: Novel group; C group: Conventional group. BD: Bile duct; HGIN: High-grade intraepithelial neoplasia; LGIN: Low-grade intraepithelial neoplasia; GIN: Glandular intraepithelial neoplasia; NT: Normal tissue.

Table 2 Comparison of blood and body indexes

		N group	C group	P value
Fever		17.4% (4/23)	41.5% (22/53)	0.0421
Breathing ratea (/m)		18.09 ± 1.04	19.60 ± 7.43	0.335
Pulse (/m)a	Value	79.70 ± 7.62	84.68 ± 18.84	0.226
	> 90/m	0 (0/23)	15.1% (8/53)	0.0491
Abdominal pain scoreb		2.09 ± 2.59	1.75 ± 1.93	0.585
Drop in hemoglobinc (g/L)		0 (0/23)	22.6% (12/53)	0.0141
WBC (109/L)	Value	8.84 ± 3.05	9.54 ± 3.39	0.395
	Abnormal	13.0 (3/23)	30.2% (16/53)	0.113
C-RP (mg/L)	Value	1.43 ± 2.66	2.93 ± 5.62	0.252
	Abnormal	4.8% (1/21)	9.5% (4/42)	0.510
AMY (u/L)		354.20 ± 399.12	324.35 ± 320.12	0.731
LPS (u/L)		2052.68 ± 4220.83	1555.89 ± 2047.35	0.493
Hyperamylasemia		39.1% (9/23)	49.1% (26/53)	0.425

^aThe lowest value in 2 d after operation.

^bPain score: 0, no; 2, slight; 4, mild; 6, moderate; 8, serious; 10, severe.

^cCount those differences larger than 20g/L between pre- and post-operation and hemoglobin lower than 120 g/L post-operation at the same time.

¹P ≤ 0.05. N group: Novel group; C group: Conventional group; WBC: White blood count; C-RP: C-reactive protein; AMY: Serum amylase; LPS: Serum lipase.

Table 3 Comparison of adverse events

		N group	C group	P value
Bleeding rate (%)		0 (0/23)	20.75 (11/53)	0.0281
Perforation rate (%)		0 (0/23)	5.66 (3/53)	0.549
Pancreatitis	Non	21	36	0.0431
	Milda	1	12
	Severea	1	5
Cholangitis rate (%)		0 (0/23)	1.89 (1/53)	1.000
MOD rate (%)		0 (0/23)	11.3 (6/53)	0.169
Total complication rate (%)		13.0 (3/23)	41.5 (22/53)	0.0181

^aCount mild pancreatitis as 1 point and severe one as 2 points.

¹P ≤ 0.05. N group: Novel group; C group: Conventional group; MOD: Multiple organ dysfunction.