Copyright ©The Author(s) 2020.
World J Gastroenterol. Oct 21, 2020; 26(39): 5944-5958
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.5944
Table 1 Technical characteristics of the currently available device-assisted endoscopes
DAE system type
Endoscope model
Optical field of view
Optical depth of field
Endoscope distal outer diameter
Endoscope channel inner diameter
Endoscope working length
Overtube outer diameter
Image enhancement
Fujifilm Corporation (Tokyo, Japan)DBEEN-580T1402-100 mm9, 4 mm3, 2 mm200 cm13, 2 mmFICE
DBEEN-580XP1402-100 mm7, 5 mm2, 2 mm200 cm11, 6 mmFICE
DBEEI-580BT1402-100 mm9, 4 mm3, 2 mm156 cm13, 2 mmFICE
Pentax Medical (Tokyo, Japan)DBE on demand using BGEG-EYE34-i10L/F1402-100 mm11, 5 mm3, 8 mm170 cmNAi-scan OE
DBE on demand using BGEG-EYE38-i10L/F1402-100 mm13, 2 mm3, 8 mm170 cmNAi-scan OE
DBE on demand using BGEG-EYE38-i10F21402-100 mm13, 2 mm3, 8 mm150 cmNAi-scan OE
Olympus (Tokyo, Japan)SBESIF-Q1801403-100 mm9, 2 mm2, 8 mm200 cm13, 2 mmNBI
SBESIFH290S1403-100 mm9, 2 mm3, 2 mm152 cm13, 2 mmNBI
SESIF-Y0019 Motorized spiral overtube1402-100 mm11, 3 mm3, 2 mm168 cm31, 1 mm max1;18, 1 mm distal2NBI
NaviAid, Smart Medical Systems, (Ra’anana, Israel)BGENo specific scope requiredNANANANANANANA
Spirus Medical (Stoughton, United States)SENo specific scope requiredNANANANANA14, 5 mmNA
Table 2 Available studies on diagnostic yield and impact on patient management of device assisted enteroscopy in adult Crohn’s disease patients
Ref.DAE system typeStudy designCD patients (n)
Diagnostic yield (%)
Impact on patient management (%)
Mensink et al[36], J Gastroenterol 2009DBERetrospective0406075
Kondo et al[33], J Gastroenterol 2010DBERetrospective25504753
Möschler et al[34], Endoscopy 2011DBEProspective19347NA
Schulz et al[24], Dig Endosc 2014DBERetrospective16069NA
Navaneethan et al[25], Endosc Int Open 2014SBE or DBERetrospective2243 2753NA53
Christian et al[35], World J Gastrointest Endosc 2016Retrograde SBERetrospective2941.417
Rahman et al[26], Gastrointest Endosc 2015DBERetrospective433879877782
Tun et al[27], Eur J Gastroenterol Hepatol 2016DBERetrospective1000 NA 45
Holleran et al[28], Scand J Gastroenterol 2018SBERetrospective1339397769
Table 3 Available study on device assisted enteroscopy in pediatric inflammatory bowel disease
DAE system type
Study design
Patients (n)
Previous diagnostic work-up
Impact on patient management (%)
Therapeutic procedure
Di Nardo et al[29], Gastrointest Endosc 2012SBEProspectiveSuspected CD = 16, known CD = 14MRI and CESuspected CD = 87%, known CD = 64%Balloon dilation = 5 ptsNot reported
de Ridder et al[30], Gastrointest Endosc 2012SBEProspectiveSuspected CD = 14, known CD = 6MRI and USSuspected CD = 57%, known CD = 83%NANot reported
Uchida et al[32], Pediatr Int 2012DBEProspectiveSuspected CD = 8, known CD = 4Upper GI endoscopy, colonoscopy and SB-contrast studySuspected CD = 75%, known CD = 75%Balloon dilation = 1 ptNot reported
Urs et al[31], J Pediatr Gastroenterol Nutr 2014DBEProspectiveSuspected CD = 3, known CD = 5CESuspected CD = 66%, known CD = 100%NANot reported
Broide et al[19], J Pediatr Gastroenterol Nutr 2020BGEProspectiveSuspected IBD = 15, known IBD = 16NANANANot reported
Table 4 Available studies on endoscopic balloon dilation using balloon-assisted enteroscopy for small bowel stricture in adult Crohn’s disease patients
DAE system type
Study design
CD patients (n)
Dilation diameter (mm), mean (range)
Technical success (%)
Clinical efficacy (%)
Dilatations (n), mean per patient (range)
Perforation (%)
Observation period (mo), mean (range)
Symptom recurrence (%)
Fukumoto et al[37], Gastrointest Endosc 2007DBERetrospective23NANA7435, (1.52; 1-6)012, (1-40)26
Pohl et al[38], Eur J Gastroenterol Hepatol 2007Push enteroscopyNA1017, (12-20)806015, (1.5; 1-3)010, (4-16)40
Ohmiyaet al[39], Gastrointest Endosc 2009DBERetrospective16NA, (8-20)9669NA016, (2-43)31
Despottet al[40], Gastrointest Endosc 2009DBEProspective1115.4, (12-20)737318, (2; 1-3)920.5, (2-41)25
Hirai et al[41], Dig Endosc 2010DBERetrospective25NA, (12-18)727255, (2.2; 1-4)011, (6-29)22
Kondo et al[33], J Gastroenterol 2010DBERetrospective8NA10087.518, 1.5 (1-2)0NANA
Gill et al[42], Ther Adv Gastroenterol 2014DBERetrospective1013.5, (10-16.5)807017, (1.8; 1-4)20NA14
Hirai et al[43], Dig Endosc 2014DBERetrospective65NA, (12-18)8080NA1.5NA 48
Navaneethan et al[25], Endosc Int Open 2014BAE (SBE/DBE)Retrospective6NA1001007, (1.16; 1-2)16NANA
Sunada et al[44], Inflamm Bowel Dis 2016DBERetrospective8512.4, (8–20)NA87321, (3.8; 1–14)541.9, (0–141)78.5
Holleran et al[28], Scand J Gastroenterol 2018SBERetrospective1313, (12-15)1008014, (1; 1-2)08, (2-16)23
Hirai et al[45], Journal of Crohn's and Colitis 2018SBE and DBEProspective9515, (8-20)947090, (1; 1-2)024, (NA)NA