TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma

Table 1 Association between transducin (β)-like 1 X-linked receptor 1 expression and the clinicopathological parameters of pancreatic ductal adenocarcinoma cells

Parameter	Category	Case number	TBL1XR1 expression
			Number of positive cases, n (%)	χ2	P value
Age (yrs)	< 60	40	27 (67.5)	0.214	0.652
	≥ 60	50	36 (72.0)
Sex	Male	59	41 (69.5)	0.021	1.000
	Female	31	22 (71.0)
Histopathological subtypes	High	3	2 (66.7)	0.146	0.929
	Middle	51	35 (68.6)
	Low	36	26 (72.2)
TNM stage	1-II	12	4 (33.3)	8.864	0.006b
	III-IV	78	59 (75.6)
Tumor size	< 3 cm	60	42 (66.7)	0.952	0.465
	≥ 3 cm	30	23 (76.7)
Tumor location	Head	37	30 (81.1)	3.674	0.065
	Body/tail	53	33 (62.3)
Lymph node metastasis	Negative	61	44 (72.1)	0.409	0.624
	Positive	29	19 (65.5)

^bP < 0.01. TBL1XR1: Transducin (β)-like 1 X-linked receptor 1; PDAC: Pancreatic ductal adenocarcinoma; TNM: Tumor-node-metastasis.

Table 2 Univariate log-rank analysis of overall survival

Parameter	Category	Case number	Median survival time (mo)	P value
			(95%CI)
Age (yrs)	< 60	40	10.0 (4.8-15.2)	0.413
	≥ 60	50	9.7 (7.41–12.0)
Sex	Male	59	9.9 (6.7-13.1)	0.983
	Female	31	9.9 (8.1-12.0)
Histopathological subtypes	High	3	25.0 (-)	0.760
	Middle	51	10.3 (8.1–11.7)
	Low	36	8.7 (6.0-11.4)
TNM stage	1-II	12	25.0 (18.1-31.9)	< 0.001c
	III-IV	78	8.0 (5.5-10.5)
Tumor size	< 3 cm	60	9.8 (8.6-11.0)	0.251
	≥ 3 cm	30	8.3 (4.8-11.8)
Tumor location	Head	37	9.3 (7.0-11.7)	0.095
	Body/tail	53	11.0 (6.0-16.0)
Lymph node metastasis	Negative	61	12.0 (7.9-16.1)	0.047a
	Positive	29	7.6 (5.3-9.8)
TBL1XR1 expression	Low	27	18.9 (10.9-26.9)	< 0.001c
	High	63	7.0 (5.7-8.3)

^aP < 0.05,

^cP < 0.001. TBL1XR1: Transducin (β)-like 1 X-linked receptor 1; CI: Confidence interval; TNM: Tumor-node-metastasis.

Table 3 Multivariate analysis of overall survival

Parameter	Category	Hazard ratio	95%CI	P value
Age (yrs)	< 60	0.139	0.907 (0.544–1.514)	0.709
	≥ 60
Sex	Male	0.013	1.031 (0.613–1.734)	0.908
	Female
Histopathological subtypes	High	0.536	1.184 (0.754–1.859)	0.464
	Middle
	Low
TNM stage	1-II	5.692	3.046 (1.220–7.604)	0.017a
	III-IV
Tumor size	< 3 cm	1.297	1.378 (0.794–2.394)	0.255
	≥ 3 cm
Tumor location	Head	3.450	1.487 (0.978–2.261)	0.063
	Body/tail
Lymph node metastasis	Negative	7.855	2.231 (1.273–3.909)	0.005b
	Positive
TBL1XR1 expression	Low	13.951	3.507 (1.815–6.774)	< 0.001c
	High

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.TBL1XR1: Transducin (β)-like 1 X-linked receptor 1; CI: Confidence interval; TNM: Tumor-node-metastasis.