Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy?

Table 1 Studies measuring drain amylase content for predicting postoperative pancreatic fistula after gastrectomy in patients with gastric cancer

Ref.	Sample size	Surgical procedure	POD 1		POD 3		Definition of POPF
			Data available	Cut-off	Data available	Cut-off
Sano et al[3], 1997	102	OTG, D1 - ≥ D2	Yes	4000 IU/L	No	NG	D-AMY > 3 times more than S-AMY for ≥ 7 days
Iwata et al[2], 2010	372	Gastrectomy, D1 - ≥ D2	Yes	1000 IU/L	No	NG	ISGPF definition (grade A/B/C)
Tomimaru et al[4], 2011	172	TG, D1 plus - D2	Yes	5000 IU/L	No	NG	ISGPF definition (grade B/C)
Miki et al[6], 2011	104	TG, D2	Yes	3398 IU/L	No	NG	ISGPF definition (grade B/C)
Kobayashi et al[7], 2015	448	Gastrectomy, D1 - ≥ D2	Yes	1949 IU/L	No	NG	C-D classification (grade III or higher)
De Sol et al[5], 2015	53	Gastrectomy,D2	N0	NG	Yes	D-AMY > 3 times more than S-AMY	ISGPF definition (grade B/C)
Kanda et al[8], 2016	265	LDG, D1 plus - D2	Yes	904 IU/L	Yes	Retained at ≥ 31.2% of D-AMY on POD 1	C-D classification (grade II or higher)
Taniguchi et al[9], 2017	591	Gastrectomy D1- ≥ D2	Yes	2900 IU/L	Yes	2100 IU/L	ISGPF definition (grade B/C)
Kamiya et al[10], 2018	801	Gastrectomy D1 plus - ≥ D2	Yes	2218 IU/L	Yes	555 IU/L	C-D classification (grade III or higher)
Wakahara et al[12], 2019	327	Gastrectomy D0-D2	No	NG	Yes	761 IU/L	C-D classification (grade II or higher)

POPF: Postoperative pancreatic fistula; POD: Postoperative day; OTG: Open total gastrectomy; D-AMY: Amylase content of drainage tube; S-AMY: Serum amylase content; ISGPF: International Study Group on Pancreatic Fistula; NG: Not given or reported in the study; TG: Total gastrectomy; C-D classification: Clavien-Dindo classification; LDG: Laparoscopic distal gastrectomy.