Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2020; 26(14): 1594-1600
Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1594
Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1594
Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy?
Koki Nakanishi, Mitsuro Kanda, Yasuhiro Kodera, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Junichi Sakamoto, Tokai Central Hospital, Kakamigahara 504-8601, Japan
Author contributions: Nakanishi K wrote the paper; Nakanishi K, Kanda M, Sakamoto J, and Kodera Y critically revised the article.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mitsuro Kanda, FACS, MD, PhD, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. m-kanda@med.nagoya-u.ac.jp
Received: December 24, 2019
Peer-review started: December 24, 2019
First decision: January 12, 2020
Revised: January 13, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 14, 2020
Peer-review started: December 24, 2019
First decision: January 12, 2020
Revised: January 13, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 14, 2020
Core Tip
Core tip: Many studies investigating postoperative pancreatic fistula after gastrectomy, including measurement of drain amylase content (D-AMY) as a predictive factor. This article reviews previous studies and looks to the future of measuring D-AMY in patients after gastrectomy. Several studies have reported that the high D-AMY on postoperative day 1 or day 3 was an independent risk factor for postoperative pancreatic fistula. However, issues for clinical use remain unresolved, including the ideal timing of measurement, optimal cut-off value and intervention after prediction. Prospective clinical trials might be indispensable for D-AMY to become a common marker in clinical practice.