Published online Apr 14, 2020. doi: 10.3748/wjg.v26.i14.1594
Peer-review started: December 24, 2019
First decision: January 12, 2020
Revised: January 13, 2020
Accepted: March 22, 2020
Article in press: March 22, 2020
Published online: April 14, 2020
Core tip: Many studies investigating postoperative pancreatic fistula after gastrectomy, including measurement of drain amylase content (D-AMY) as a predictive factor. This article reviews previous studies and looks to the future of measuring D-AMY in patients after gastrectomy. Several studies have reported that the high D-AMY on postoperative day 1 or day 3 was an independent risk factor for postoperative pancreatic fistula. However, issues for clinical use remain unresolved, including the ideal timing of measurement, optimal cut-off value and intervention after prediction. Prospective clinical trials might be indispensable for D-AMY to become a common marker in clinical practice.