Hepatocellular carcinoma: Can LI-RADS v2017 with gadoxetic-acid enhancement magnetic resonance and diffusion-weighted imaging improve diagnostic accuracy?

doi:10.3748/wjg.v25.i5.622

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 25, Issue 5

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6745)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

478

WORD

293

HTML

3333

Figures (1-3)

231

Tables (1-3)

144

Sum=4479

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1066

Download

1200

Sum=2266

Feb 7, 2019 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (20)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Feb 7, 2019; 25(5): 622-631
Published online Feb 7, 2019. doi: 10.3748/wjg.v25.i5.622

Table 1 Parameters of diffusion-weighted imaging, T1-weighted imaging, T2-weighted imaging, and VIBE sequence

Parameter	DWI	In/out of phase	T2-weighted imaging	VIBE
Parameter	DWI	T1-weighted imaging	T2-weighted imaging	VIBE
Repetition time (ms)	5600	81	2160	3.95
Echo time (ms)	68	1.4	100	1.92
Field of view (mm²)	380 × 289	400 × 325	433 × 433	400 × 296
Scan matrix	100 × 76	352 × 286	320 × 20288	352 × 256
Slice thickness (mm)	6	6	6	2
Slice gap (mm)	1	2.7	2.7	0
Number of excitation	…	1	2	1

DWI: Diffusion-weighted imaging.

Table 2 Patients’ baseline characteristics

Characteristic	Value
Clinical information
Age (yr)	50.31 ± 10.87 (range: 26-77)
Male/female	157/46
Etiology of liver disease
Hepatitis B virus	194 (95.57%)
Hepatitis C virus	8 (3.94%)
Both hepatitis B and C virus	1 (0.49%)
Tumor size (cm)	Median 5.3 (range: 1.1-12.8)
AFP level (ng/mL)	102.3 ng/mL (range 1.2-15926.0)
Serum AST (≥ 35 IU/L)	107 (52.7%)
Serum ALT (≥ 40 IU/L)	82 (40.4%)

AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransaminase.

Table 3 Sensitivity, specificity, and accuracy of the liver imaging reporting and data system category for diagnosing hepatocellular carcinoma with gadoxetic-acid enhanced magnetic resonance imaging

Group	DWI	Sensitivity (100%)	Specificity (100%)	Accuracy (100%)	PPV (100%)	NPV (100%)	Youden index
LR-5	A-DWI	61.2 (101/165)	92.5 (74/80)	71.4 (175/245)	94.4 (101/107)	53.6 (74/138)	0.537
LR-5	P-DWI	61.2 (101/165)	92.5 (74/80)	71.4 (175/245)	94.4 (101/107)	53.6 (74/138)	0.537
LR-4/5	A-DWI	73.9 (122/165)	80 (64/80)	75.9 (186/245)	88.4(122/138)	59.8 (64/107)	0.539
LR-4/5	P-DWI	87.9 (145/165)	80 (64/80)	85.3 (209/245)	90.1 (145/161)	76.2 (64/84)	0.679
LR-4/5/M	A-DWI	75.8 (125/165)	58.8 (47/80)	70.2 (172/245)	79.1 (125/158)	54 (47/87)	0.346
LR-4/5/M	P-DWI	87.9 (145/165)	58.8 (47/80)	78.4 (192/245)	81.5 (145/178)	70.1 (47/67)	0.467
LR-4/5/TIV	A-DWI	75.8 (125/165)	75 (60/80)	75.5 (185/245)	86.2 (125/145)	60 (60/100)	0.508
LR-4/5/TIV	P-DWI	89.7 (148/165)	75 (60/80)	84.9 (208/245)	88.1 (148/168)	77.9 (60/77)	0.647

A-DWI: Absence of diffusion-weighted imaging; P-DWI: Presence of diffusion-weighted imaging; PPV: Positive predictive value; NPV: Negative predictive value.

Citation: Zhang T, Huang ZX, Wei Y, Jiang HY, Chen J, Liu XJ, Cao LK, Duan T, He XP, Xia CC, Song B. Hepatocellular carcinoma: Can LI-RADS v2017 with gadoxetic-acid enhancement magnetic resonance and diffusion-weighted imaging improve diagnostic accuracy? World J Gastroenterol 2019; 25(5): 622-631
URL: https://www.wjgnet.com/1007-9327/full/v25/i5/622.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i5.622