Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2 and 3 in northwest China

doi:10.3748/wjg.v25.i44.6551

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 25, Issue 44

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6535)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-4) series.

Item

Count

PDF

463

WORD

277

HTML

2551

Figures (1-1)

210

Tables (1-4)

172

Sum=3673

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

939

Download

1923

Sum=2862

Nov 28, 2019 (publication date) through Apr 26, 2024

Times Cited of This Article

Times Cited (12)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Nov 28, 2019; 25(44): 6551-6560
Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6551

Table 1 Regimens of direct-acting antivirals for treatment of hepatitis C virus infection

Patients		Genotype 1	Genotype 2	Genotype 3
Chronic hepatitis	Treatment naïve	SOF + LDV for 12 wk	SOF + RBV for 12 wk	SOF + DCV for 12 wk
Chronic hepatitis	Treatment experienced	SOF + LDV for 12 wk	SOF + RBV for 16-20 wk	SOF + DCV + RBV for 12 wk or 24 wk without RBV
Cirrhosis, compensated or decompensated		SOF + LDV + RBV for 12 wk or 24 wk without RBV	SOF + RBV for 16-20 wk	SOF + DCV + RBV for 24 wk

A fixed dose combination of sofosbuvir (SOF) and ledipasvir was administered once per day. One tablet each of SOF and daclatasvir should be taken daily. Ribavirin was 1000 or 1200 mg/d in patients < 75 kg or ≥ 75 kg, respectively. SOF: Sofosbuvir (400 mg); LDV: Ledipasvir (90 mg); DCV: Daclatasvir (60 mg); RBV: Ribavirin (200 mg).

Table 2 Baseline characteristics of hepatitis C virus patients based on genotype

	Total (n = 366)	Genotype 1 (n = 216)	Genotype 2 (n = 126)	Genotype 3 (n = 24)
Age (yr)	52.2 ± 12.0	51.7 ± 12.8	53.6 ± 10.0	49.8 ± 14.1
Gender (males, %)	174 (47.5)	101 (46.8)	62 (49.2)	11 (45.8)
TBIL (µmol/L)	19.63 ± 10.60	19.62 ± 10.77	19.52 ± 10.72	20.07 ± 8.47
ALT (U/L)	53.48 ± 45.18	56.95 ± 47.79	51.55 ± 40.35	54.33 ± 36.91
AST (U/L)	51.89 ± 39.12	50.79 ± 41.96	48.9 ± 33.74	53.5 ± 33.31
Albumin (g/L)	36.6 ± 8.6	38.9 ± 8.6	41.2 ± 8.5	36.6 ± 8.6
TCHO (mmol/L)	3.85 ± 0.60	3.81 ± 0.58	3.85 ± 0.66	4.14 ± 0.41
Hemoglobin (mg/dL)	120.3 ± 23.6	120.4 ± 23.3	121.2 ± 23.2	114.8 ± 27.9
Platelets (10⁹/L)	147.7 ± 75.8	144.5 ± 74.8	155.7 ± 77.8	134.3 ± 73.6
AFP (ng/mL)	4.69 ± 5.79	5.01 ± 7.33	4.30 ± 2.02	3.81 ± 2.27
Treatment experienced, n (%)	50 (13.7)	26 (12.0)	20 (15.9)	4 (16.7)
Cirrhosis, n (%)	154 (42.1)	96 (43.5)	46 (36.5)	12 (50)
HBV/HCV co-infection, n (%)	25 (6.8)	12 (5.6)	9 (7.1)	4 (16.7)
Diabetes mellitus, n (%)	17 (4.6)	12 (5.6)	4 (3.2)	1 (4.2)
Hypertension, n (%)	24 (6.6)	16 (7.4)	8 (6.3)	0 (0)
Fatty liver disease, n (%)	52 (14.2)	31 (14.4)	16 (12.7)	5 (20.8)

TBil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TCHO: Total cholesterol; AFP: Alpha fetoprotein; HCV: Hepatitis C virus; HBV: Hepatitis B virus.

Table 3 Baseline characteristics of hepatitis C virus patients based on severity of liver disease

	Non-cirrhosis (n = 212)	Cirrhosis (compensated and decompensated) (n = 154)	P value
Age (yr)	48.5 ± 12.6	57.3 ± 8.9	< 0.001
Gender (males, %)	115 (54.2)	77 (50.0)	0.423
TBil (µmol/L)	15.04 ± 8.78	25.95 ± 9.59	< 0.001
ALT (U/L)	41.74 ± 43.00	64.88 ± 44.81	0.029
AST (U/L)	31.47 ± 26.67	68.12 ± 43.44	0.034
Albumin (g/L)	44.5 ± 4.5	33.0 ± 8.6	< 0.001
TCHO (mmol/L)	3.86 ± 0.55	3.82 ± 0.66	0.349
Hemoglobin (mg/dL)	135.3 ± 10.6	99.5 ± 20.4	0.002
Platelets (10⁹/L)	195.3 ± 59.8	86.1 ± 32.2	< 0.001
AFP (ng/mL)	4.04 ± 1.79	5.58 ± 8.61	0.045
Log10 HCV RNA (IU/mL)	6.6 ± 0.8	6.3 ± 1.3	0.040
LSM (kPa)	5.71 ± 1.7	10.26 ± 5.1	< 0.001
Fibrosis 4 score	1.43 ± 1.0	7.49 ± 6.0	< 0.001
APRI	1.06 ± 0.9	2.3 ± 1.5	< 0.001

TBil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TCHO: Total cholesterol; AFP: Alpha fetoprotein; LSM: Liver stiffness measurement; APRI: AST-to-platelet ratio index.

Table 4 Baseline data for patients with and without sustained virological responses (by modified intention-to-treat analysis)

	Non-SVR12 (n = 11)	SVR12 (n = 315)	P value
Age (yr)	54.1 ± 13.5	51.8 ±11.9	0.098
Gender (males, %)	4 (36.4)	162 (51.4)3	0.080
TBil (µmol/L)	20.16 ± 10.13	19.58 ± 10.69	0.184
ALT (U/L)	62.45 ± 53.85	52.28 ± 46.14	0.034
AST (U/L)	42.73 ± 30.30	47.29 ± 39.74	0.516
Albumin (g/L)	37.7 ± 10.0	39.6 ± 8.6	0.214
TCHO (mmol/L)	3.93 ± 0.59	3.85 ± 0.60	0.879
Hemoglobin (mg/dL)	119.1 ± 15.0	119.5 ± 23.8	0.497
Platelets (10⁹/L)	165.6 ± 68.4	144.9 ± 76.0	0.167
AFP (ng/mL)	5.03 ± 4.49	4.77 ± 6.15	0.407
Log10 HCV RNA (IU/mL)	6.5 ± 0.6	6.5 ± 1.0	0.450
Cirrhosis, n (%)	5 (45.5)	138 (43.8)	0.621
Treatment experienced, n (%)	1 (9.1)	49 (15.6)	0.052

TBil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TCHO: Total cholesterol; AFP: Alpha fetoprotein; HCV: Hepatitis C virus; SVR12: Sustained virological response at post-treatment week 12.

Citation: Yang Y, Wu FP, Wang WJ, Shi JJ, Li YP, Zhang X, Dang SS. Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2 and 3 in northwest China. World J Gastroenterol 2019; 25(44): 6551-6560
URL: https://www.wjgnet.com/1007-9327/full/v25/i44/6551.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i44.6551