Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6551
Peer-review started: September 6, 2019
First decision: October 14, 2019
Revised: November 8, 2019
Accepted: November 13, 2019
Article in press: November 13, 2019
Published online: November 28, 2019
Core tip: Direct-acting antiviral agent (DAA)-based regimens are currently the preferred treatment for hepatitis C. However, there is not enough data reporting the results of real-world research, especially in countries such as China where DAAs have only been approved for using in recent years. We found that there was no significant difference in sustained virological responses (SVR) between patients with different genotypes and liver statuses. Patients with lower alanine aminotransferase levels at baseline who achieved end of treatment response were more likely to achieve SVR at post-treatment week 12. Also, we found two cases of special adverse events. One case involved facial and bilateral lower extremity edema, which was due to drug-drug interactions, and the other case showed an interesting change in lipid levels while the patient was on medication.