Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation

Table 1 Criteria for scoring disease activity index

Score	Weight loss, %	Stool consistency	Occult/gross bleeding
0	None	Normal	Normal
1	1-5
2	5-10	Loose stools	Hemoccult positive
3	10-15
4	> 15	Diarrhea	Gross bleeding

Table 2 Criteria for histology analysis for scoring colonic damage

Colon damage score	0	1	2	3
Crypt architecture damage	None	Regeneration	Destruction
Edema in sub-mucosa	None	Mild	Moderate	Severe
Inflammatory cells infiltration	None/rare	Lamina propria	Sub-mucosa	Muscle layer