Observational Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Sep 21, 2018; 24(35): 4069-4076
Published online Sep 21, 2018. doi: 10.3748/wjg.v24.i35.4069
Table 1 Patient demographics and clinical features
FeatureData
Study patients67
Age (yr)40 (27-73)
Male sex46 (70)
Disease duration (yr)17 (8-51)
Age at diagnosis (yr)25 (12-59)
Colitis activity index score20 (0-8)
Primary sclerosing cholangitis3 (5), missing n = 2
Colorectal cancer in first degree relative3 (5), missing n = 5
Previous dysplasia in colon3 (5), missing n = 3
Treatment
Aminosalicylate158 (92), missing n = 3
Steroids112 (18), missing n = 4
Azathioprine14 (6)
Antitumour necrosis factor14 (6), missing n = 1
Table 2 Histologic diagnosis of the seven neoplastic lesions detected among the 67 total patients with long-standing and extensive ulcerative colitis
SexAge (yr)LGD
HGDAdenocarcinomaTotal
Targeted biopsyNontargeted biopsyTargeted biopsyTargeted biopsy
Male341741113
Male67121
Male49112
Male3311
Female3611
Male4411
Female5222
Total4114221
Table 3 Morphology and histology findings for the 16 bioptic sites of the 67 total patients with long-standing and extensive ulcerative colitis
MorphologyHistologyn
Targeted biopsy
Nonpolypoid
Flat lesionNo neoplasia26
LGD2
HGD11
Superficial elevatedNo neoplasia10
HGD11
Adenocarcinoma1
Polypoid
PedunculatedNo neoplasia1
LGD1
NonpedunculatedLGD1
Sessile with central ulcerationHGD21
SessileAdenocarcinoma11
IND1
Nontargeted biopsy
No neoplasia307
LGD11
Total366
Table 4 Histologic grade of inflammation in the biopsies taken from all 67 patients
Grade of inflammation
Mayo 01Mayo 1Mayo 2Mayo 3No signs of previous inflammationTotal
No dysplasia/IND1338333393345
LGD31200015
HGD022004
CRC011002
Total1369836393366