Clinical correlation of B7-H3 and B3GALT4 with the prognosis of colorectal cancer

Table 1 Expression of B7 homolog 3 and β-1,3-galactosyltransferase-4 in colorectal cancer patients and their correlation with clinicopathological parameters

Clinicopathological parameter	Case (n)	B7-H3 expression		P value	B3GALT4 expression		P value
		Low	High		Low	High
Gender				0.616			0.213
Male	124	35	89		63	61
Female	99	31	68		42	57
Age (yr)				0.259			0.791
< 60	87	22	65		40	47
≥ 60	136	44	92		65	71
Tumor location				0.361			0.905
Colon	88	23	65		41	47
Rectum	135	43	92		64	71
Colon cancer site				0.119			0.352
Right-sided	37	7	30		20	17
Left-sided	186	59	127		85	101
Depth of tumor invasion				0.049			0.527
T1/2	64	25	39		28	36
T3/4	159	41	118		77	82
Lymph node metastasis				0.433			0.145
N0	116	37	79		60	56
N1/2	107	29	78		45	62
Distant metastasis				0.034			0.425
Yes	16	1	15		6	10
No	207	65	142		99	108
TNM stage				0.297			0.068
I/II	113	37	76		60	53
III/IV	110	29	81		45	65
Neural invasion				0.146			0.683
Yes	32	6	26		14	18
No	191	60	131		91	100
Vascular invasion				0.079			0.585
Yes	35	6	29		15	20
No	188	60	128		90	98
Mucinous adenocarcinoma				0.579			0.506
Yes	20	7	13		8	12
No	203	59	144		97	106
Differentiation				0.017			0.186
Poor	73	14	59		39	34
Moderate/well	150	52	98		66	84

B7-H3: B7 homolog 3; B3GALT4: β-1,3-galactosyltransferase-4.

Table 2 Correlation between B7 homolog 3 and β-1,3-galactosyltransferase-4 expression in colorectal cancer

B3GALT4 expression	B7-H3 expression		r	P value
	Low	High
Low	41	60	0.219	0.001
High	25	97

B7-H3: B7 homolog 3; B3GALT4: β-1,3-galactosyltransferase-4.

Table 3 Univariate and multivariate Cox proportional hazards analyses of overall survival in patients with colorectal cancer

Clinical parameter	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Gender (male vs female)	0.999 (0.637-1.566)	0.995
Age (≥ 60 vs < 60) (yr)	0.951 (0.603-1.500)	0.829
Tumor location (rectum vs colon)	1.351 (0.863-2.117)	0.188
Colon cancer site (left-sided vs right-sided)	0.970 (0.534-1.760)	0.919
Depth of tumor invasion (T3/4 vs T1/2)	2.522 (1.362-4.670)	0.003	1.807 (0.949-3.443)	0.072
Lymph node metastasis (N1/2 vs N0)	2.922 (1.801-4.739)	0.000	0.322 (0.077-1.341)	0.119
Distant metastasis (yes vs no)	9.353 (5.206-16.804)	0.000	4.635 (2.224-9.660)	0.000
TNM stage (III/IV vs I/II)	3.497 (2.114-5.783)	0.000	7.490 (1.636-34.280)	0.009
Neural invasion (yes vs no)	2.240 (1.320-3.802)	0.003	0.800 (0.410-1.561)	0.514
Vascular invasion (yes vs no)	2.531 (1.529-4.188)	0.000	1.962 (1.082-3.558)	0.026
Mucinous adenocarcinoma (yes vs no)	1.063 (0.488-2.314)	0.877
Differentiation (poor vs moderate/well)	0.799 (0.504-1.267)	0.340
B7-H3 (high vs low)	1.781 (1.027-3.089)	0.040	1.289 (0.721-2.307)	0.392
B3GALT4 (high vs low)	1.597 (1.007-2.533)	0.047	1.209 (0.721-2.307)	0.392
B7-H3 and B3GALT4 (high vs low)	0.737 (0.552-0.983)	0.038	1.153 (0.845-1.572)	0.369
B7-H3 high (B3GALT4 high vs low)	2.283 (1.289-4.042)	0.005
B7-H3 low (B3GALT4 high vs low)	0.321 (0.091-1.127)	0.076

B7-H3: B7 homolog 3; B3GALT4: β-1,3-galactosyltransferase-4.