Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors

Table 1 Clinicopathological data of the 63 patients with gastrointestinal stromal tumors

Characteristic	Patients (n = 63)
	Number	Percentage (%)
Gender
Male	33	52.4
Female	30	47.6
Age (yr)
≥ 56	32	50.8
< 56	31	49.2
Tumor location
Stomach	35	55.6
Duodenum	12	19.0
Jejunoileum	14	22.2
Colon	2	3.2
Tumor size (cm)
< 2	11	17.5
2-5.9	20	31.7
6-10	18	28.6
> 10	14	22.2
NIH risk grade
Very low	10	15.9
Low	19	30.1
Moderate	10	15.9
High	24	38.1
Mitotic figures per 50 HPFs
0	11	17.5
1-4	35	55.6
5-9	6	9.4
>10	11	17.5
Mucosal invasion
Yes	33	52.4
No	30	47.6

HPFs: High-power fields.

Table 2 Relationship between raf kinase inhibitory protein expression and clinical and pathological characteristics of gastrointestinal stromal tumors

Characteristic	Number	RKIP expression		P value
		Positive (≥ 3)	Negative (< 3)
Gender
Male	33	19	14	0.547
Female	30	15	15
Age (yr)
≥ 56	32	20	12	0.167
< 56	31	14	17
Tumor location
Stomach	35	16	19	0.503
Duodenum	12	8	4
Jejunoileum	14	9	5
Colon	2	1	1
Tumor size (cm)
< 2	11	10	1	< 0.011
2-5	20	15	5
6-10	18	5	13
> 10	14	4	10
NIH risk grade
Very low	10	8	2	< 0.011
Low	19	16	3
Moderate	10	3	7
High	24	7	17
Mitotic figures per 50 HPFs
0	11	8	3	0.218
1-4	35	20	15
5-9	6	2	4
> 10	11	4	7
Mucosal invasion
Yes	33	13	20	0.0151
No	30	21	9

¹RKIP positive percentage were compared using the χ test, P < 0.05 were considered statistically significant. RKIP: Raf kinase inhibitory protein; HPFs: High-power fields.

Table 3 Multivariate analysis of factors affecting prognosis of gastrointestinal stromal tumors (n = 63)

	B	SE	Wald	df	significance	Exp (B)
NIH risk grade	1.299	0.624	4.337	1	0.037	3.664
Age	-0.008	0.019	0.186	1	0.667	0.992
Sex	-0.500	0.561	0.795	1	0.373	0.606
RKIP expression	1.049	0.678	2.395	1	0.122	2.855
Mitotic figures	0.087	0.283	0.095	1	0.758	1.091
Tumor size	-0.121	0.435	0.078	1	0.781	0.886
Tumor location	0.269	0.351	0.589	1	0.443	1.309

NIH: National Institutes of Health; RKIP: Raf kinase inhibitory protein.