Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis

Table 1 Comparison of untreated and treated patients with autoimmune hepatitis

Characteristic	Untreated group (n = 17)		Treated group (n = 19)		P value
	mean ± SD	95%CI	mean ± SD	95%CI
Age (yr)	62.9 ± 18.6	53.4-72.5	41.4 ± 16.8	33.30-49.5	0.001
BMI (kg/m2)	27.2 ± 6.3	24.0-30.5	28.2 ± 6.8	24.9-31.5	0.65
Serum albumin	3.81 ± 0.8	3.39-4.23	4.0 ± 0.43	3.78-4.2	0.4
Serum ALP	117.6 ± 74.7	76.3-159.0	109.4 ± 45.6	85.9-132.9	0.19
Serum ALT	298.8 ± 459.9	62.3-535.3	144.5 ± 217.8	39.5-249.4	0.22
Serum AST	238.2 ± 313.1	77.2-399.1	110.0 ± 144.4	42.6-178.0	0.12
AST/ALT	1.0 ± 0.4	0.8-1.27	0.9 ± 0.41	0.8-1.0	0.38
APRI	2.9 ± 3.47	1.1-4.67	3.2 ± 5.8	0.36-6.0	0.85
FIB-4	5.99 ± 4.94	3.4-8.53	2.7 ± 3.3	1.1-4.3	0.025
Platelet	178.9 ± 78.0	138.8-219	193.3 ± 99.0	145.6-241.0	0.63
INR	1.1 ± 0.2	1.0-1.24	1.14 ± 0.3	1.0-1.3	0.96
Total bilirubin	1.5 ± 2.3	0.3-2.69	1.5 ± 1.9	0.5-2.5	0.96
Gamma globulin	2.3 ± 0.9	1.9-2.9	2.2 ± 0.9	1.6-2.8	0.61
Mean LS (kPa)	4.1 ± 1.6	3.2-4.9	4.5 ± 2.0	3.5-5.4	0.51

ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; APRI: AST to platelet ratio index; BMI: Body mass index; FIB-4: Fibrosis 4 test; INR: International normalization ratio; LS: Liver stiffness.

Table 2 Spearman rank correlation analysis results between variables and histological fibrosis stage and inflammation grade

Test	Fibrosis stage			Inflammation grade
	Correlation	95%CI	P value	Correlation	95%CI	P value
AST	0.21	-0.13-0.50	0.2236	0.29	-0.043-0.56	0.0870
ALT	0.02	-0.31-0.35	0.8916	0.31	-0.02-0.58	0.0660
APRI	0.44	0.14-0.68	0.0064	0.39	0.07-0.64	0.0184
AST/ALT	0.40	0.08-0.65	0.0143	0.01	-0.32-0.34	0.9432
FIB-4	0.52	0.23-0.72	0.0012	0.24	-0.09-0.53	0.1497
Platelet	-0.48	-0.69--0.18	0.0032	-0.04	-0.37-0.29	0.7972
INR	0.49	0.19-0.71	0.0022	0.36	0.04-0.62	0.0294
Total Bil	0.36	0.030-0.63	0.0338	0.31	-0.03-0.58	0.0784
LS	0.83	0.69-0.91	< 0.0001	0.19	-0.14-0.49	0.2465

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; APRI: AST to platelet ratio index; FIB-4: Fibrosis 4 test; INR: International normalization ratio; LS: Liver stiffness.

Table 3 Area under the receiver operating characteristic curves of magnetic resonance elastography and laboratory tests for prediction of advanced fibrosis and cirrhosis in autoimmune hepatitis

	Advanced fibrosis			Cirrhosis
	AUC	SE	95%CI	AUC	SE	95%CI
LS	0.966	0.0278	0.845-0.998	0.980	0.0175	0.867-1.000
ALT	0.526	0.0998	0.354-0.695	0.582	0.1010	0.406-0.744
AST	0.618	0.0964	0.441-0.774	0.691	0.0909	0.515-0.834
AST/ALT	0.681	0.0904	0.505-0.826	0.736	0.0860	0.563-0.868
APRI	0.728	0.0932	0.554-0.862	0.776	0.0789	0.606-0.898
FIB_4	0.786	0.0760	0.618-0.905	0.803	0.0750	0.636-0.916
INR	0.770	0.0770	0.596-0.891	0.800	0.0880	0.635-0.915
Platelet	0.802	0.0780	0.636-0.916	0.763	0.0904	0.592-0.888

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; APRI: AST to platelet ratio index; FIB-4: Fibrosis 4 test; INR: International normalization ratio; LS: Liver stiffness.