Stricturing Crohn’s disease-like colitis in a patient treated with belatacept

Table 1 Case reports of colitis induced by cytotoxic T-lymphocyte-associated antigen 4-Ig fusion proteins

	Type of CTLA-4-Ig fusion protein	Delay between	Endoscopic findings	Histological findings	CTLA-4-Ig	Colitis treatment	Evolution of the colitis
		CTLA-4-Ig introduction and colitis (mo)			withdrawal
Amezcua-Guerra et al[7] Gut 2005	Abatacept	15	UC-like colitis	Lymphoplasmocytic infiltration/cryptitis/Intraluminal abscesses	Yes	Mesalazine	Clinical remission
Motohashi et al[8] Case 1 Scand J Gastroenterol 2014	Abatacept	25	UC-like colitis	Neutrophil infiltration/crypt abscesses	Yes	Infliximab + Mesalazine	NA
Motohashi et al[8] Case 2 Scand J Gastroenterol 2014	Abatacept	5	UC-like colitis	Neutrophil infiltration/crypt abscesses	Yes	Mesalazine + Prednisolone + Granulocytapheresis	NA
Present case	Belatacept	23	CD-like colitis	Ulcerations/crypt abscesses/	Yes	Prednisolone	Clinical and endoscopic remission
				lymphocytes and neutrophil infiltration

CD: Crohn’s disease; CTLA-4: Cytotoxic T-lymphocyte-associated antigen 4; NA: Not available; UC: Ulcerative colitis.