Basic Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Dec 21, 2017; 23(47): 8291-8299
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8291
Table 1 Summary of stool samples collected and analyzed
Tumor locationTotal collected samplesSuccessful DNA extractionSuccessful sequencingNumber of cases with only known mutationsNumber of cases with
Mutations, all
Stomach413532 (78)5 (15.6)8 (25)
Carcinoma38322936
Intestinal type18171511
Diffuse type20151425
Benign33322
Hamartoma11100
Dysplasia11111
NET11111
Colorectal464240 (87)12 (30)12 (30)
Carcinoma40373599
Benign65533
Adenoma43322
Dysplasia11100
Leiomyoma11111
Healthy controls141313 (92.9)02 (15)
Total10190851722
Table 2 COSMIC and novel mutations detected by Ion Torrent sequencing
HistopathologyCases IDAge, yrSexTNM stagingGeneMutation typeCOSMIC No.
Stomach
AC (D)366FT2N0SMARCB1p.T72KNovel
AC (D)1480FT4aNxM1APCp.D1570NNovel
CDH1p.V82ANovel
HRASp.V44MNovel
NRASp.K135RNovel
AC (D)3965FT1aN0M0EGFRp.A750TCOSM1651572
DDR2p.E523KNovel
AC (D)4343MT4bNxM1PTENp.E256GNovel
AC (D)7778MTxNxM1APCp.A1582PCOSM4170230
AC (I)10069MT3N3M1APCp.A1582PCOSM4170230
NET1167M5% PRCDKN2Ap.V126ICOSM13778
Dysplasia7877MT0N0M0APCp.A1582PCOSM4170230
Colorectal
AC2070MT3N0M0KITp.N564SCOSM30732
AC1271FT3N1bM0APCp.A1582PCOSM4170230
TP53p.P72ACOSM3738520
AC2179MT2N0APCp.A1582PCOSM4170230
AC2264FT2N0STK11p.F354LCOSM21360, COSM4169323
SMOp.N202SCOSM5979442
AC2353MTxNxM1APCp.A1582PCOSM4170230
AC3164MT2N0TP53p.Y205DCOSM43844
AC5569MT3N0M0KRASp.G12VCOSM520
TP53p.T172fsCOSM44371
AC6863MT3N0M0TP53p.Y163HCOSM43846
AC2877FT1N0KRASp.G12DCOSM521
AKT1p.E17KCOSM34142, COSM33765
Adenoma2481MAPCp.E1295*COSM18961
Adenoma1964FNRASp.Q61RCOSM584, COSM28048
FBXW7p.R505CCOSM22975, COSM33844
APCp.S1465fsCOSM18873, COSM19688 COSM19332, COSM18931, COSM13864
ERBB2p.V842ICOSM14065, COSM1666633
SMARCB1p.R377CCOSM3972885
Leiomyoma9469FTP53p.R306*COSM10663, COSM145026
Healthy controls
C 2F27ALKp.L1190PNovel
C 8F33STK11p.Y36HNovel