Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice

Table 1 Comparison of mouse weight (13^th week)

Group	Treatment	n	Weight (g) (mean ± SD)
1	Control (BD)	5	32.60 ± 1.81
2	AOM/DSS (MO)	5	28.63 ± 1.601
3	AOM/DSS + 1% EGCG (EG)	8	30.95 ± 1.3823

¹Significantly different from group 1 (P = 0.006);

²No significant difference from group 1 (P = 0.088);

³No significant difference from group 2 (P = 0.18). AOM: Azoxymethane. EGCG: Epigallocatechin gallate; DSS: Dextran sodium sulfate.

Table 2 Effects of epigallocatechin gallate on azoxymethane-induced aberrant crypt foci in FVB mice (8^th week): distribution of aberrant crypt foci along the large bowel and comparison of aberrant crypt foci in different parts

Group	Treatment	n	Length (cm)	Rate (%)	Number of ACF
					Proximal	Distal	Entire
1	Control	5	9.73 ± 0.76	/	/	/	/
2	AOM/DSS (MO)	8	8.27 ± 0.37	100	1.13 ± 1.36	12.50 ± 3.67	13.13 ± 3.02
3	AOM/DSS + 1% EGCG	8	8.68 ± 0.471	75	0.63 ± 0.87	4.75 ± 3.702	5.38 ± 4.242

¹Different from group 2 (P < 0.05);

²Significantly different from group 2 (P < 0.01). AOM: Azoxymethane; DSS: Dextran sodium sulfate; EGCG: Epigallocatechin gallate; ACF: Aberrant crypt foci.

Table 3 Statistics of valid sequences and trimmed sequences in different group

Group	Valid sequences (mean)	Trimmed sequences (mean)
BD Group	75116-49662 (615022)	65936-45406 (54162)
MO Group	82804-25360 (56551 )	73924-22895 (50842 )
EG Group	79506-40705 (65124)	74876-36795 (59693 )