Systemic immune-inflammation index for predicting prognosis of colorectal cancer

doi:10.3748/wjg.v23.i34.6261

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World Journal of Gastroenterology

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Retrospective Cohort Study

World J Gastroenterol. Sep 14, 2017; 23(34): 6261-6272
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6261

Table 1 Baseline patient characteristics based on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammation index n (%)

	Cases	NLR		P value	PLR		P value	SII		P value
	Cases	≤ 2.7	> 2.7	P value	≤ 210	> 210	P value	≤ 340	> 340	P value
Age (yr)				0.005			0.904			0.063
≤ 60	698 (50.5)	480 (53.2)	218 (45.3)		437 (50.3)	261 (50.7)		233 (54.2)	465 (48.8)
> 60	685 (49.5)	422 (46.8)	263 (54.7)		431 (49.7)	254 (49.7)		197 (45.8)	488 (51.2)
Gender				0.067			0.422			0.927
Male	808 (58.4)	511 (56.7)	297 (61.7)		500 (57.6)	308 (59.8)		252 (58.6)	536 (58.3)
Female	575 (41.6)	391 (43.3)	184 (38.3)		368 (42.4)	207 (40.2)		178 (41.4)	397 (41.7)
Tumor location				< 0.001			0.008			0.060
Right-sided	324 (23.4)	185 (20.5)	139 (28.9)		183 (21.1)	141 (27.4)		87 (20.2)	237 (24.9)
Left-sided	1059 (76.6)	717 (79.5)	342 (71.1)		685 (78.9)	374 (72.3)		343 (79.8)	716 (75.1)
Histological type				< 0.001			0.020			< 0.001
Well-differentiated	1126 (81.4)	761 (84.4)	365 (75.9)		723 (83.3)	403 (78.3)		376 (87.4)	750 (78.7)
Poorly differentiated	257 (18.6)	141 (15.6)	116 (24.1)		145 (16.7)	112 (21.7)		54 (12.6)	203 (21.3)
Tumor size				< 0.001			< 0.001			0.003
≤ 5 cm	936 (67.7)	660 (73.2)	276 (57.4)		617 (71.1)	319 (61.9)		315 (73.3)	621 (65.2)
> 5 cm	447 (32.3)	242 (26.8)	205 (42.6)		251 (28.9)	196 (38.1)		115 (26.7)	332 (34.8)
T stage				< 0.001			< 0.001			< 0.001
T1	67 (4.8)	45 (5.0)	22 (4.6)		54 (4.9)	13 (4.8)		38 (8.8)	29 (3.0)
T2	256 (18.5)	197 (21.8)	59 (12.3)		170 (19.9)	86 (16.7)		104 (24.2)	152 (15.9)
T3	748 (54.1)	507 (56.2)	241 (50.1)		475 (54.7)	273 (53.0)		232 (54.0)	516 (54.1)
T4	312 (22.6)	153 (17.0)	159 (33.1)		169 (19.5)	143 (27.8)		56 (13.0)	256 (26.9)
N stage				< 0.001			0.021			< 0.001
N0	487 (35.2)	353 (39.1)	134 (27.9)		325 (37.4)	162 (31.5)		196 (45.6)	291 (30.5)
N1	416 (30.1)	277 (30.7)	139 (28.9)		261 (30.1)	155 (30.1)		121 (28.1)	295 (31.0)
N2	308 (22.3)	188 (20.8)	120 (24.9)		190 (21.9)	118 (22.9)		77 (17.9)	231 (24.2)
N3	172 (12.4)	84 (9.3)	88 (18.3)		92 (10.6)	80 (15.5)		36 (8.4)	136 (14.3)
M stage				< 0.001			< 0.001			< 0.001
M0	1115 (80.6)	774 (85.8)	341 (70.9)		726 (83.6)	389 (75.5)		386 (89.8)	729 (76.5)
M1	268 (19.4)	128 (14.2)	140 (29.1)		142 (16.4)	126 (24.5)		44 (10.2)	224 (23.5)
TNM stage				< 0.001			0.001			< 0.001
I	187 (13.5)	141 (15.6)	46 (9.6)		133 (15.3)	54 (10.5)		92 (21.4)	95 (10.0)
II	515 (37.2)	368 (40.8)	147 (30.6)		335 (38.6)	180 (35.0)		171 (39.8)	344 (36.1)
III	413 (29.9)	265 (29.4)	148 (30.8)		258 (29.7)	155 (30.1)		123 (28.6)	290 (30.4)
IV	268 (19.4)	128 (14.2)	140 (29.1)		142 (16.4)	126 (24.5)		44 (10.2)	224 (23.5)
Chemotherapy				< 0.001			< 0.001			< 0.001
No	684 (49.5)	488 (54.1)	196 (40.7)		472 (54.4)	212 (41.2)		243 (56.5)	441 (46.3)
Yes	699 (50.5)	414 (45.9)	285 (59.3)		396 (45.6)	303 (58.8)		187 (43.5)	512 (53.7)

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index.

Table 2 Univariate and multivariate Cox regression analysis of the associations between clinical parameters and overall survival in patients with colorectal cancer

	Univariate analysis				Multivariate analysis
	χ² value	HR	95%CI	P value	χ² value	HR	95%CI	P value
Age	22.965	1.405	1.223-1.614	< 0.001	38.131	1.561	1.355-1.798	< 0.001
Gender	0.017	-	-	0.896
Tumor location	0.269	-	-	0.604
Histological type	22.178	1.493	1.264-1.764	< 0.001
Tumor size	1.166	-	-	0.280
T stage	71.702	1.498	1.364-1.645	< 0.001
N stage	113.905	1.432	1.340-1.529	< 0.001
M stage	239.937	3.415	2.923-3.989	< 0.001	26.390	1.951	1.512-2.517	< 0.001
TNM stage	207.252	1.785	1.650-1.932	< 0.001	22.971	1.345	1.191-1.518	< 0.001
NLR status	40.824	1.582	1.374-1.821	< 0.001
PLR status	23.604	1.416	1.231-1.649	< 0.001	12.618	1.294	1.123-1.492	< 0.001
SII status	173.330	3.529	2.925-4.258	< 0.001	141.427	3.163	2.616-3.824	< 0.001
Chemotherapy	76.931	1.894	1.642-2.184	< 0.001

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio.

Table 3 Univariate and multivariate Cox regression analysis of the associations between clinical parameters and PFS in patients with colorectal cancer

	Univariate analysis				Multivariate analysis
	χ² value	HR	95%CI	P value	χ² value	HR	95%CI	P value
Age	21.774	1.373	1.202-1.569	< 0.001	34.479	1.499	1.310-1.716	< 0.001
Gender	0.144	-	-	0.705
Tumor location	0.509	-	-	0.476
Histological type	20.091	1.447	1.231-1.701	< 0.001
Tumor size	1.095	-	-	0.295
T stage	59.847	1.419	1.299-1.550	< 0.001
N stage	86.718	1.354	1.270-1.443	< 0.001
M stage	221.926	3.172	2.725-3.692	< 0.001	31.580	2.024	1.583-2.589	< 0.001
TNM stage	179.589	1.673	1.552-1.804	< 0.001	15.414	1.255	1.121-1.406	< 0.001
NLR status	36.441	1.518	1.325-1.738	< 0.001
PLR status	20.826	1.369	1.196-1.567	< 0.001
SII status	159.123	2.988	2.521-3.542	< 0.001	129.495	2.717	2.287-3.228	< 0.001
Chemotherapy	61.159	1.716	1.499-1.965	< 0.001

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio.

Citation: Chen JH, Zhai ET, Yuan YJ, Wu KM, Xu JB, Peng JJ, Chen CQ, He YL, Cai SR. Systemic immune-inflammation index for predicting prognosis of colorectal cancer. World J Gastroenterol 2017; 23(34): 6261-6272
URL: https://www.wjgnet.com/1007-9327/full/v23/i34/6261.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i34.6261