Anti-apoptotic effect of banhasasim-tang on chronic acid reflux esophagitis

Table 1 Composition of the banhasasim-tang formulation used in this study

Herb	Amount in g
Pinelliae rhizoma	1.67
Scutellariae radix	1.00
Zingiberis rhizoma siccus	0.83
Ginseng radix	1.00
Glycyrrhizae radix	1.00
Jujubae fructus	1.00
Coptidis rhizoma	0.33

Banhasasim-tang Ex. granule was obtained from Hankook Shinyak Corp (Nonsan-si, Chungcheongnam-do, South Korea) in a pack of 3.5 g.

Table 2 Body weight change and food intake

Group	Body weight change in g, following surgery					Food intake in g/d
	0 d	4 d	7 d	14 d	21 d
Drug treatment	-	-	1 d	8 d	15 d
Normal rats	169 ± 2.4	170 ± 2.4	219 ± 2.6	278 ± 3.9	329 ± 5.6	27.32 ± 0.47
CARE modeled rats
Untreated	166 ± 2.2	137 ± 2.0b	142 ± 2.7b	150 ± 7.5b	178 ± 12.8b	12.27 ± 0.63b
BHSST-treated	167 ± 1.8	135 ± 1.8	146 ± 3.8	169 ± 10.1	194 ± 19.1	14.99 ± 0.58d

Data are presented as mean ± SE (n = 7).

^bP < 0.001 vs normal rats;

^dP < 0.01 vs untreated CARE modeled rats.

Table 3 Hematological analyses

Group	ROS	TBARS
	fluorescence/min·mL	nmol/mL
Normal rats	182 ± 14.5	3.56 ± 0.13
CARE modeled rats
Untreated	289 ± 31.9b	7.60 ± 0.77b
BHSST-treated	134 ± 59.2c	5.56 ± 0.36

Data are presented mean ± SE (n = 7).

^bP < 0.01 vs normal rats;

^cP < 0.05 vs untreated CARE modeled rats. CARE: Chronic acid reflux esophagitis; ROS: Reactive oxygen species; TBARS: 2-Thiobarbituric acid reactive substance.