Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer

Table 1 Comparison of clinicopathological characteristics of patients with or without para-aortic nodesinvolvement

	Total(n = 151)	PALNs-(n = 126)	PALNs+(n = 25)	P value
Mean/median age	65/67	65/66	65/68
Sex
F	75	59	16	0.13
M	76	67	9
Type of surgery
PD	146	122	24	1.00
TP	5	4	1
Vascular resection	29	21	8	0.09
Tumor (T)
1	6	6	0	0.50
2	17	14	3	1.00
3	107	90	17	0.80
4	21	16	5	0.50
Nodes status (N)
Neg	39	39	0	0.003
Pos	112	87	25
Grading (G)
1	15	11	4	0.20
2	89	77	12	0.20
3	47	38	9	0.60
Radicality
Yes	113	100	13	0.009
No	38	26	12
Adjuvant therapy
Yes	143	120	23	0.74
No	8	6	0

PALNs: Para-aortic lymph nodes; PD: Pancreaticoduodenectomy; TP: Total pancreatectomy; Grading 1, 2, 3: Well, moderate, poor differentiated cancer.

Table 2 Univariate overall survival analysis of prognostic factors for patients with pancreatic cancer

	Mean survival time (mo) (95%CI)	Median survival time (mo) (95%CI)	P value
Grading (G)
1-2	39.55 (32.36-46.74)	24.00 (19.87-28.13)	< 0.001
3	16.42 (12.86-19.98)	14.00 (12.57-15.43)
Radicality
R0	35.88 (29.46-42.31)	22.00 (18.36-25.64)	0.004
R1	19.99 (12.62-27.38)	13.00 (11.45-14.55)
Stage
I-II	34.82 (28.47-41.18)	21.00 (17.79-24.21)	0.03
III-IV	23.29 (14.70-31.87)	14.00 (11.40-16.59)
Lymph nodes status
Neg	43.29 (30.37-56.21)	25.00 (17.055-32.95)	0.04
Pos	27.27 (22.52-32.02)	18.00 (14.65-21.35)
Number of positive lymph nodes
< 3	26.62 (20.87-32.35)	19.00 (13.09-24.90)	0.74
> 3	28.39 (20.04-36.74)	17.00 (12.93-21.07)
Lymph node ratio
≤ 0.13	31.31 (23.69-38.93)	20.00 (15.57-24.43)	0.28
0.13-0.2	25.11 (13.23-36.99)	14.00 (9.87-18.13)
> 0.2	23.29 (16.98-29.61)	18.00 (14.57-21.43)
Para-aortic lymph nodes status
Neg	42.06 (29.22-54.89)	25.00 (17.17-32.83)	0.02
Pos	27.27 (22.54-32.02)	18.00 (14.64-21.35)

Grading 1-2: Well-moderately differentiated cancer; Grading 3: Poor differentiated cancer.

Table 3 Univariate disease-free survival analysis of prognostic factors for patients with pancreatic cancer

	Mean DFI time (mo) (95%CI)	Median DFI time (mo) (95%CI)	P value
Grading (G)
1-2	32.438 (24.808-40.068)	13.000 (8.597-17.403)	< 0.01
3	10.438 (8.011-12.865)	8.000 (7.183-8.817)
Radicality
R0	29.886 (22.892-36.880)	12.000 (9.280-14.720)	0.001
R1	12.708 (6.744-18.671)	8.000 (6.256-9.744)
Staging
I-II	27.222 (20.732-33.711)	12.000 (9.814-14.186)	0.126
III-IV	19.772 (9.939-29.604)	8.000 (6.976-9.0224)
Lymph nodes status
Neg	34.386 (20.868-47.904)	13.000 (9.523-16.477)	0.106
Pos	21.468 (16.504-26.432)	10.000 (7.686-12.314)
Number of positive lymph nodes
< 3	30.817 (21.628-40.006)	10.000 (6.746-13.254)	0.150
> 3	20.326 (14.615-26.036)	11.000 (8.082-13.918)
lymph node ratio
≤ 0.13	30.576 (22.593-38.560)	12.000 (9.211-14.789)	0.155
0.13-0.2	17.500 (5.595-29.405)	8.000 (6.614-9.366)
> 0.2	17.397 (11.191-23.603)	13.000 (8.840-17.160)
Para-aortic lymph nodes status
Neg	28.206 (21.656-34.756)	12.000 (9.808-14.192)	0.005
Pos	11.957 (6.132-17.781)	8.000 (6.853-9.147)

DFI: Disease-free survival; Grading 1-2: Well-moderately differentiated cancer; Grading 3: Poor differentiated cancer.

Table 4 Multivariate analysis for overall survival and disease-free survival in 151 patients resected for pancreatic adenocarcinoma

	Overall survival		Disease-free survival
	HR (95%CI)	P value	HR (95%CI)	P value
Grading	2.518 (1.677-3.780)	0.000	2.266 (1.498-3.428)	0.000
Stage	1.137 (0.676-1.915)	0.628	0.960 (0.570-1.615)	0.877
PALNs status	1.376 (0.776-2.441)	0.275	1.519 (0.869-2.656)	0.143

PALNs: Para-aortic node status.