Renin angiotensin system in liver diseases: Friend or foe?

doi:10.3748/wjg.v23.i19.3396

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May 21, 2017 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2017; 23(19): 3396-3406
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3396

Table 1 Main and opposite actions of both renin angiotensin system axes

Organ/tissue	ACE-Ang II- AT₁ axis	ACE2-Ang-(1-7)-Mas axis
Blood vessels	Vasoconstriction	Vasodilation
Heart	Hypertrophic, arrithmogenic	Anti-hypertrophic, anti-arrithmogenic
Kidney	Inflammation, fibrosis	Anti-inflammatory, anti-fibrogenic
Lung	Alergic, fibrosis	Anti-alergic, anti-fibrosis
Brain	Ischemia	Reduction of ischemia
Adipose tissue	Increase insulin resistance	Decrease insulin resistance

ACE: Angiotensin-converting enzyme; Ang II: Angiotensin II, AT₁: Angiotensin type 1 receptor; Ang-(1-7): Angiotensin-(1-7); Mas: Angiotensin-(1-7) receptor.

Citation: Simões e Silva AC, Miranda AS, Rocha NP, Teixeira AL. Renin angiotensin system in liver diseases: Friend or foe? World J Gastroenterol 2017; 23(19): 3396-3406
URL: https://www.wjgnet.com/1007-9327/full/v23/i19/3396.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i19.3396