CXCR7/CXCL12 axis is involved in lymph node and liver metastasis of gastric carcinoma

Table 1 Association between CXCL12 and CXCR7 expression and clinical characteristics in patients with gastric cancer

Factor	n	CXCR12 expression				CXCR7 expression
		-	+	χ2	P value	-	+	χ2	P value
Gender				0.008	0.930			1.643	0.200
Male	72	20	52			12	60
Female	88	25	63			22	66
Age (yr)				0.040	0.841			2.497	0.114
< 56	66	18	48			10	56
≥ 56	94	27	67			24	70
Tumor diameter (cm)				5.006	0.025			5.694	0.017
< 3.5	70	26	44			21	49
≥ 3.5	90	9	25			13	77
Lauren’s classification				5.452	0.020			4.034	0.045
Diffuse type	40	17	23			13	27
Intestinal type	120	28	92			21	99
Differentiation				4.718	0.030			0.107	0.803
Well-moderately	78	23	55			13	65
Poorly	42	5	37			8	34
Depth of invasion				7.057	0.008			5.502	0.019
T1 + T2	66	26	40			20	46
T3 + T4	94	19	75			14	80
Clinical stages				3.944	0.047			5.125	0.024
I + II	69	25	44			22	54
III + IV	91	20	71			12	72
Lymph node metastasis				10.435	0.001			10.980	0.001
+	96	18	78			12	84
-	64	27	37			22	42
Liver metastasis				3.606	0.044			4.402	0.027
+	29	3	26			1	28
-	91	25	66			18	73

P < 0.05 was considered as statistically significant.

Table 2 The relationship between the clinical pathological characteristics and CXCL12/CXCR7 expression in gastric carcinoma

Factor	n	CXCR12+CXCR7+	CXCL12+CXCR7-/CXCL12-CXCR7+	CXCR12-CXCR7-	r	P value
Diameter (cm)					0.205	0.009
< 3.5	70	41	11	18
≥ 3.5	90	69	11	10
Depth of invasion					0.240	0.002
T1 + T2	66	37	11	18
T3 + T4	94	73	11	10
Clinical stages					0.200	0.001
I + II	69	41	9	19
III + IV	91	69	13	9
Lymph node metastasis					0.310	0.000
-	64	34	11	19
+	96	86	11	9
Liver metastasis					0.227	0.016
-	91	60	16	15
+	29	26	2	1

P < 0.05 was considered as statistically significant.