Pharmacological cyclin dependent kinase inhibitors: Implications for colorectal cancer

Table 1 Cyclin dependent kinases-inhibitors that have entered clinical trials

Drug name	Cyclin/CDK targeted	Manufacturer	Potential implications
Flavopiridol	Cyclin D and CDK-4/6	Sanofi-Aventis, Bridgewater, NJ, United States	Renal cancer, Prostate cancer, colon cancer, non-Hodgkin’s lymphoma[23]
	Cyclin E and CDK-2
	Cyclin A and CDK-2
	Cyclin A and CDK-1
PD-00332991	Cyclin D and CDK-4/6	Pfizer, New York, NY, United States	Breast cancer[25] Gastrointestinal tumors[26]
P276-00	Cyclin D and CDK-4/6	Piramal Life Sciences Limited, Mumbai, India	Mantle Cell Lymphoma[27]
	Cyclin E and CDK-2
	Cyclin A and CDK-2
PHA-848125	Cyclin D and CDK-4/6	Nerviano Medical Sciences, Nerviano, Italy	Metastatic solid tumors[27,28]
	Cyclin E and CDK-2
	Cyclin A and CDK-2
LY2835219	Cyclin D and CDK-4/6	Eli Lilly, Indianapolis, IN, United States	Lung cancers[29]
LEE011	Cyclin D and CDK-4/6	Novartis, Basel, Switzerland	Gastrointestinal cancers[30] Breast Cancer[31]
AZD5438	Cyclin D and CDK-4/6	Astra Zeneca, London, England	Solid malignancies[32]
	Cyclin E and CDK-2
	Cyclin A and CDK-2
	Cyclin A and CDK-1
BAY 1000394	Cyclin D and CDK-4/6	Bayer, Barmen, Germany	Small cell lung cancer[33]
	Cyclin E and CDK-2
	Cyclin A and CDK-2
	Cyclin B and CDK-1
P1446A-05	Cyclin D and CDK-4/6	Piramal Life Sciences Limited, Mumbai, India	Advanced malignancies[34]
SNS-032	Cyclin E and CDK-2	Sunesis Pharmaceutical, South San Francisco, CA, United States	Multiple myeloma, chronic lymphocytic leukemia[35]
	Cyclin A and CDK-2
	Cyclin B and CDK-1
Bryostatin-1	Cyclin E and CDK-2	Ellisville, MO, United States	Metastatic renal cell carcinoma, soft tissue sarcoma[36]
	Cyclin A and CDK-2
	Cyclin B and CDK-1
Roscovitine	Cyclin E and CDK-2	Cyclacel Pharmaceuticals, Short Hills, NJ, United States	Advanced malignancies[37]
	Cyclin A and CDK-2
	Cyclin B and CDK-1
Dinaciclib	Cyclin E and CDK-2	Merck, Whitehouse Station, NJ, United States	Breast Cancer[38]
	Cyclin A and CDK-2
	Cyclin B and CDK-1
UCN-01	Cyclin E and CDK-2	Sigma-Aldrich. St. Louis, MO,	Breast Cancer[39]
	Cyclin A and CDK-2	United States
	Cyclin B and CDK-1

CDK: Cyclin dependent kinase.