Review
Copyright ©The Author(s) 2016.
World J Gastroenterol. Aug 14, 2016; 22(30): 6841-6850
Published online Aug 14, 2016. doi: 10.3748/wjg.v22.i30.6841
Table 1 Differentiation into quiescent hepatic stellate cells, hepatic stellate cells, and cancer-associated fibroblasts
Quiescent hepatic stellate cellsHepatic stellate cellsCancer associated
(fibroblast)(myofibroblast)fibroblasts
MorphologySpindle shape with numerous intracellular droplets[16]Spindle shapeSpindle shape
OriginMesoderm[17]Quiescent hepatic stellate cellsActivated hepatic stellate cells
LocationSpace of Disse, sinusoidal spacesPeriportal lesionTumor stroma
Biological markersDesmin[17]αSMA, p75NTR[17]αSMA, COL11A1[13]
FunctionStore the vitamin A and fatWound healing fibrosisTumor progression
Cytokines-Production of the collagens, PDGF, TGF-β, TNF-α, IL-6, IL-1β[25,26]production of the collagens, TGF-β, HGF, FGF, VEGF, IL-6[42-58], etc