TCF7L2 rs7903146 polymorphism is associated with gastric cancer: A case-control study in the Venezuelan population

Table 1 Characteristics of the study population n (%)

Variables	Controls	Gastric cancer
Overall	129	122
Sexa
Male	63 (48.8)	88 (72.1)
Female	66 (51.2)	34 (27.9)
Agea, mean ± SD (yr)	58.81 ± 9.99	62.32 ± 14.29
Histological differentiation
Well		14 (11.5)
Moderated		56 (45.9)
Poor		52 (42.6)

^aP < 0.05 vs control.

Table 2 Association of TCF7L2 rs7903146 and rs12255372 polymorphisms with gastric cancer n (%)

SNP	Risk allele	HWE (control), P value	Inheritance model	Genotype	Control	Gastric cancer	OR (95%CI)1	P value1
rs7903146	T	0.741			n = 129	n = 122
				CC	73 (56.6)	56 (45.9)	1
			Codominant	CT	49 (38.0)	48 (39.3)	1.30 (0.75–2.25)	0.345
				TT	7 (5.4)	18 (14.8)	3.61 (1.36–9.61)	0.010
			Dominant	CC	73 (56.6)	56 (45.9)	1
				CT + TT	56 (43.4)	66 (54.1)	1.58 (0.94–2.64)	0.082
			Recessive	CC + CT	122 (94.6)	104 (85.2)	1
				TT	7 (5.4)	18 (14.8)	3.11 (1.22–7.92)	0.017
rs12255372	T	0.053			n = 129	n = 117
				GG	85 (65.9)	78 (66.7)	1
			Codominant	GT	35 (27.1)	32 (27.3)	1.06 (0.59–1.92)	0.841
				TT	9 (7.0)	7 (6.0)	1.11 (0.38–2.25)	0.849
			Dominant	GG	85 (65.9)	78 (66.7)	1
				GT + TT	44 (34.1)	39 (33.3)	1.06 (0.61–1.83)	0.839
			Recessive	GG + GT	120 (93.0)	110 (94.0)	1
				TT	9 (7.0)	7 (6.0)	1.02 (0.36–2.90)	0.972

¹Adjusted by age and gender; Statistical power (1-β) was calculated for all observed P values. HWE: Hardy-Weinberg equilibrium; SNP: Single nucleotide polymorphism.

Table 3 Distribution of TCF7L2 rs7903146 and rs12255372 single nucleotide polymorphisms according to the degree of histological differentiation of gastric cancer n (%)

SNP	Inheritance model	Genotype	Control	M/W GC	OR (95%CI)1	P value1	P GC	OR (95%CI)1	P value1
rs7903146			n = 129	n = 70			n = 52
		CC	73 (56.6)	25 (35.7)	1		31 (59.6)	1
	Codominant	CT	49 (38.0)	36 (51.4)	2.33 (1.20–4.51)	0.012	12 (23.1)	0.57 (0.26–1.23)	0.152
		TT	7 (5.4)	9 (12.9)	5.70 (1.60–20.3)	0.007	9 (17.3)	2.99 (0.99–8.92)	0.050
	Dominant	CC	73 (56.6)	25 (35.7)	1		31 (59.6)	1
		CT + TT	56 (43.4)	45 (64.3)	2.55 (1.35–4.80)	0.004	21 (40.4)	0.88 (0.45–1.71)	0.708
	Recessive	CC + CT	122 (94.6)	61 (87.1)	1		43 (82.7)	1
		TT	7 (5.4)	9 (12.9)	2.93 (0.99–8.68)	0.053	9 (17.3)	3.65 (1.25–10.6)	0.018
rs12255372			n = 129	n = 66			n = 51
		GG	85 (65.9)	38 (57.6)	1		40 (78.4)	1
	Codominant	GT	35 (27.1)	24 (36.3)	1.44 (0.39–5.36)	0.589	8 (15.7)	0.51 (0.21–1.21)	0.129
		TT	9 (7.0)	4 (6.1)	1.63 (0.83–3.21)	0.156	3 (5.9)	0.81 (0.20–3.26)	0.770
	Dominant	GG	85 (65.9)	38 (57.6)	1		40 (78.4)	1
		GT + TT	44 (34.1)	28 (42.4)	1.58 (0.84–3.00)	0.158	11 (21.6)	0.56 (0.26–1.22)	0.145
	Recessive	GG + GT	120 (93.0)	62 (93.9)	1		48 (94.1)	1
		TT	9 (7.0)	4 (6.1)	1.15 (0.33–4.05)	0.823	3 (5.9)	0.87 (0.22–3.43)	0.844

¹Adjusted by age and gender; Statistical power (1-β) was calculated for all observed P values. W/M: Well and moderately differentiated gastric cancer; P GC: Poorly differentiated gastric cancer; SNP: Single nucleotide polymorphism.