Basic Study
Copyright ©The Author(s) 2016.
World J Gastroenterol. Jul 21, 2016; 22(27): 6224-6234
Published online Jul 21, 2016. doi: 10.3748/wjg.v22.i27.6224
Table 1 Clinical characteristics of the study subjects
Hepatitis B-associated HCC(n = 30)Hepatitis C-associated HCC(n = 38)P value
Sex (M/F)28/222/16< 0.011
Age (yr)62.6 ± 10.973.4 ± 9.7< 0.012
Albumin (g/dL)3.4 ± 0.63.4 ± 0.5NS2
Total bilirubin (mg/dL)1.2 ± 0.61.4 ± 1.3NS2
AST (U/L)75.6 ± 76.257.8 ± 31.6NS2
ALT (U/L)54.3 ± 38.449.8 ± 38.3NS2
Fasting blood glucose (mg/dL)104.5 ± 22.2113.1 ± 36.0NS2
γ-glutamyl transferase (U/L)77.0 ± 64.860.4 ± 58.1NS2
Creatinine (mg/dL)0.73 ± 0.191.01 ± 1.53NS2
Platelet count (× 103/μL)13.5 ± 8.411.7 ± 4.7NS2
Fib-4 index5.7 ± 4.46.4 ± 3.9NS2
AFP (ng/mL) ≤ 6.2 /> 6.210/208/30NS1
DCP (mAU/mL) ≤ 40 /> 4017/1324/14NS1
HBs antigen, positive300
HCV-antibody, positive038
HBV genotype (A/B/C/D)0/14/15/1NA
HCV genotype (1b/2a/2b)NA34/4/0
Table 2 Parameters of multiple logistic regression model
MetaboliteCoefficient95%CIOdds ratio95%CIP value
(Intercept)-8.01-14.0-4.141.00 × 10-3
Met0.05210.0180.09791.051.021.108.60 × 10-3
γ-Glu-Gly-Gly-17.6-35.7-5.312.23 × 10-83.18 × 10-164.93 × 10-31.97 × 10-2
Glu0.02550.01350.04541.031.011.051.30 × 10-3
Table 3 Correlation coefficients between amino acids and γ-glutamyl peptides
Amino acidγ-glutamyl peptidesSpearman R95%CIP value(two-tailed)
Ileγ-Glu-Ile0.45840.2401-0.6325< 0.0001
Alaγ-Glu-Ala0.04022-0.48980.7447
Serγ-Glu-Ser0.2117-0.46980.0831
Valγ-Glu-Val0.45650.2379-0.6311< 0.0001
Thrγ-Glu-Thr0.39090.1610-0.58050.001
Leuγ-Glu-Leu0.48980.2779-0.6562< 0.0001
Asnγ-Glu-Asn0.40120.1729-0.58850.0007
Lysγ-Glu-Lys0.29090.04915-0.50040.0161
Glnγ-Glu-Gln0.63870.4665-0.7642< 0.0001
Gluγ-Glu-Glu0.82680.7294-0.8913< 0.0001
Hisγ-Glu-His0.29820.05714-0.50640.0135
Pheγ-Glu-Phe0.48860.2765-0.6554< 0.0001
Argγ-Glu-Arg0.42580.2016-0.60760.0003
Tyrγ-Glu-Tyr0.69370.5404-0.8024< 0.0001
Aspγ-Glu-Asp0.55660.3606-0.7056< 0.0001
Metγ-Glu-Met0.54180.3420-0.6947< 0.0001
Trpγ-Glu-Trp0.34330.1070-0.54280.0042
Glyγ-Glu-Gly0.05704-0.4890.6441
Glyγ-Glu-Gly-Gly0.006012-0.49050.9612