Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer

Table 1 Number of protein expression changes in comparison between adjacent stages of colon carcinogenesis process

Comparison	Protein expression
	Downregulated	Upregulated
AD:NC (113:114)	113	86
CIS:AD (115:113)	137	102
ICC:CIS (116:115)	103	141

Table 2 Top 10 differential proteins (up-regulated and down-regulated) between different stages

No.	GN	Protein name	Cluster	AD:NC	CIS:NC	ICC:NC
1	DMBT1	Deleted in malignant brain tumors 1 protein	5	3.12	3.43	4.82
2	S100A9	Protein S100-A9	5	2.56	2.52	4.67
3	CLC	Galectin-10	5	4.21	2.50	4.54
4	S100A8	Protein S100-A8	5	1.51	1.46	3.72
5	MPO	Myeloperoxidase	6	1.22	0.09	3.12
6	OLFM4	Olfactomedin-4	5	3.89	3.01	3.02
7	LDHA	L-lactate dehydrogenase A chain	5	1.93	3.69	2.92
8	SERPINB5	Serpin B5	5	4.32	2.69	2.78
9	EPX	Eosinophil peroxidase	5	3.16	2.82	2.73
10	COL12A1	Collagen alpha-1(XII) chain	5	0.57	4.35	2.68
11	TNC	Tenascin	5	-0.48	4.41	2.33
12	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	5	2.69	3.55	2.16
13	MUC2	Mucin-2	2	-0.80	-5.21	-0.39
14	CA2	Carbonic anhydrase 2	2	-2.86	-5.08	-0.62
15	DCN	Decorin	4	-3.67	-2.03	-1.06
16	COL14A1	Collagen alpha-1(XIV) chain	2	-4.25	-3.42	-1.06
17	LUM	Lumican	4	-3.90	-1.40	-1.21
18	CA1	Carbonic anhydrase 1	2	-2.63	-4.96	-1.74
19	ITLN1	Intelectin-1	2	-2.18	-5.00	-1.91
20	ASPN	Asporin	4	-3.59	-1.36	-1.91
21	OGN	Mimecan	2	-4.35	-4.71	-2.29
22	GSTP1	Glutathione S-transferase P	7	-1.36	-1.06	-2.73
23	CKB	Creatine kinase B-type	2	-1.26	-2.98	-2.76
24	PFN1	Profilin-1	7	-0.47	0.30	-2.84
25	CHGA	Chromogranin-A	2	-3.44	-4.84	-3.20
26	TPI1	Triosephosphate isomerase	7	-0.88	-2.32	-3.75