Multi-locus genetic risk score predicts risk for Crohn’s disease in Slovenian population

Table 1 Genetic risk profile based on the genetic risk score in 33 single nucleotide polymorphisms model

GRS	Sensitivity	Specificity	+LR	-LR	+PV	-PV	+PV1	-PV1
> 4.27	98.12%	19.62%	1.22	0.10	0.15%	100.00%	11.94%	98.95%
> 4.57	93.12%	34.45%	1.42	0.20	0.17%	99.98%	13.63%	97.83%
> 5.05	75.00%	72.73%	2.75	0.34	0.33%	99.96%	23.41%	96.32%
> 5.54	35.63%	93.30%	5.32	0.69	0.63%	99.92%	37.14%	92.88%
> 5.81	10.00%	99.04%	10.42	0.91	1.24%	99.89%	53.65%	90.83%
> 5.94	6.25%	99.52%	13.02	0.94	1.54%	99.89%	59.13%	90.53%

¹PV-positive and negative predictive value for estimated prevalence of CD in targeted population with high risk (10%). LR-positive and negative likelihood ratio, PV-positive and negative predictive value for estimated prevalence of CD in Slovenian population (0.12%). GRS: Genetic risk scores; CD: Crohn’s disease; LR: Likelihood ratios; PV: Predictive value.

Table 2 Comparison of risk in different groups of individuals

Group	OR	P value	95%CI
High vs low risk	26.65	< 0.0001	11.25-63.15
High vs intermediate risk	4.06	< 0.0001	1.32-12.47
Intermediate vs low risk	5.13	< 0.0001	2.76-9.56

High-risk group: GRS > 5.54; Intermediate risk group: 4.57 < GRS ≤ 5.54; low risk group: GRS ≤ 4.57. GRS: Genetic risk scores.