Yang JF, Zhao ZH, Zhang Y, Zhao L, Yang LM, Zhang MM, Wang BY, Wang T, Lu BC. Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma. World J Gastroenterol 2016; 22(13): 3652-3662
Corresponding Author of This Article
Min-Ming Zhang, Professor, Chief, Department of Radiology, Second Afﬁliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. firstname.lastname@example.org
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1European Association for the Study of the Liver suggested non-invasive diagnosis criteria on 4-phase multidetector CT scan. EASL: European Association for the Study of the Liver; MRI: Magnetic resonance imaging.
Table 2 Summary of parameter terms used in the dual-input extended Tofts model and 2-compartment exchange model
Concentration of tracer in the tissue
Concentration of tracer in whole blood in a major feeding artery
Concentration of tracer in the portal vein
Arterial fraction of the tissue perfusion
Hematocrit in major (large) vessels
Hepatic perfusion index
Flow rate of the blood plasma through the intravascular plasma space
mL/mL per minute
Ratio of blood plasma volume to tissue volume
Ratio of EES volume to tissue volume
Efflux rate constant
Endothelial permeability surface area product
mL/mL per minute
EES: Extravascular extracellular space.
Table 3 Patients’ demographic characteristics, tumor volume, and tumor stage
1Paired t-test. NA: Not available; HPI: Hepatic perfusion index.
Citation: Yang JF, Zhao ZH, Zhang Y, Zhao L, Yang LM, Zhang MM, Wang BY, Wang T, Lu BC. Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma. World J Gastroenterol 2016; 22(13): 3652-3662