Retrospective Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Feb 21, 2015; 21(7): 2124-2130
Published online Feb 21, 2015. doi: 10.3748/wjg.v21.i7.2124
Table 1 Characteristics of patients with colorectal liver metastases n (%)
VariablePrimary hepatectomy (n = 406)Secondary hepatectomy (n = 55)P value1
Sex (M/F)266:14036:190.99
Median age (yr) (range)59.5 (26-80)58 (36-80)0.95
Number of CRLM (median, range)1 (1-8)1 (1-4)0.01
CRLM size (median, range)2.4 (0.2-7.5)2.4 (1.0-7.5)0.85
Liver metastases
Synchronous279 (69)39 (71)0.74
Metachronous127 (31)16 (29)
CRLM number
Single232 (57)41 (75)0.014
Multiple174 (43)14 (25)
CRLM treatment
Resection324 (80)25 (45)< 0.001
RFA57 (14)29 (53)
Both25 (6)1 (2)
T stage
T1 T2 T3364 (90)47 (85)0.35
T442 (10)8 (15)
N stage
N0117 (29)13 (24)0.42
N1 or N2289 (71)42 (76)
Histological differentiation2
High grade367 (90)53 (96)0.21
Low grade39 (10)2 (4)
Lymphatic invasion
(-)172 (42)16 (29)0.02
(+)129 (32)26 (47)
Vascular invasion
(-)168 (41)29 (53)0.14
(+)102 (25)10 (18)
Perineural invasion
(-)191 (47)20 (36)0.38
(+)74 (18)11 (22)
Chemotherapy
Yes373 (92)50 (91)0.79
No33 (8)5 (9)
Table 2 Cox regression proportional hazard model of disease-free survival in recurrent colorectal liver metastases
VariablePrimary hepatectomy (n = 406)
Secondary hepatectomy (n = 55)
Univariate analysisMultivariate analysis1
Univariate analysisMultivariate analysis1
P valueHR95%CIP valueP valueHR95%CIP value
Male sex0.1100.260
Age0.7500.360
Metachronous0.0020.700.42-1.160.1700.670
Multiple CRLM0.0670.0372.781.33-5.780.006
Size of CRLM0.0011.151.04-1.260.0060.260
Radiofrequency ablation0.2200.0082.841.40-5.730.004
T40.1100.530
N1 or N20.0021.170.70-1.940.5500.310
Low grade cell differentiation2< 0.0012.381.46-3.880.0010.660
Lymphatic invasion< 0.0011.501.02-2.200.0400.100
Vascular invasion< 0.0011.490.99-2.250.0580.670
Perineural invasion0.0011.320.88-1.990.1900.820
Adjuvant chemotherapy0.9500.140