Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia

Table 1 Patient sex and age distribution

Diagnosis	Sex	Mean age (range, yr)
Normal	3 M + 2 F	63.2 (42-75)b
IBD	4 M + 1 F	34.6 (23-56)
Dysplasia	3 M + 2 F	68.8 (52-76)b
Cancer	3 M + 2 F	73.6 (60-83)b
CAC	3 M + 3 F	57.5 (40-77)a

^aP < 0.05,

^bP < 0.01, IBD patients vs normal, sporadic dysplasia, sporadic cancer, and CAC patients. CAC: Colitis-associated colorectal cancer; IBD: Inflammatory bowel disease; M: Male; F: Female (n = 5-6 patients per group).

Table 2 Colitis-associated colorectal cancer patient information

Sample ID	IBD diagnosis	Duration of disease (yr)	Sex	Age (yr)	Graph symbol
1	UC	9	M	61	●
2	UC	7	M	61	■
3	CD	20	F	49	▲
4	UC	27	F	40	▼
5	UC	35	M	57	◆
6	UC	57	F	77	★

Graph symbol indicates the unique symbol used to identify each patient in Figures 2B-5B. Duration of disease indicates duration at the time of biopsy. IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease.