Towards curative therapy in gastric cancer: Faraway, so close!

Table 1 Randomized trials of surgery with and without neoadjuvant or perioperative chemotherapy in resected gastric cancer

Ref.	n	Chemotherapy	Hazard ratio for survival (95%CI)
Cunningham et al[27], 2006	503	ECF	0.75 (0.60-0.93)
Ychou et al[49], 2011	224	PF	0.69 (0.50-0.95)
Schuhmacher et al[28], 2010	144	PF	No significant survival difference

ECF: Epirubicin/cisplatin/5-fluorouracil; PF: Cisplatin/5-fluorouracil.

Table 2 Randomized trials of adjuvant chemo or chemoradiotherapy in resected gastric cancer

Ref.	n	Regimen	3 yr Disease free survival rate (%; P value)
Lee et al[41], 2012	458	XP vs XP/XRT/XP	No significant Disease free survival difference
Yu et al[45], 2012	68	5FU/LV vs 5FU /LV/RT	44.1 vs 67.7 (P < 0.05)
Kim et al[44], 2012	90	5FU/LV vs 5FU/LV/RT	No significant Disease free survival difference
Kwon et al[46], 2010	61	5FU/LV vs 5FU/LV/RT	No significant Disease free survival difference
Bamias et al[43], 2010	147	DP vs DP/RT	No significant Disease free survival difference

X: Capecitabine; 5-FU: 5-fluorouracil; LV: Leucovorin; P: Cisplatin; D: docetaxel; RT: Radiotherapy (45 Gy).

Table 3 Criteria for adequate surgical margins

	German S3	JGCA
Resection margins	Oral, aboral circumferential	Proximal
Proximal resection margins	5 cm (intestinal type)	-cT1: 2 cm
	8 cm (difuse type)	-cT2-T4:
		3 cm (expansive)
		5 cm (infiltrative)

Table 4 Selected randomized controlled trials studying the extent of the lymph node dissection for patients with gastric cancer

Ref.	Year published	Region	Extent of Lymph node dissection	Patients(n)	Morbidity	Mortality	5 yr overall survival (%)
Dent et al[62]	1988	South Africa	D1	22	22%	0%	N/A
			D2	21	43%	0%	N/A
BonenKamp et al[59,66]	1995	The Netherlands	D1	380	25%	4%	45
			D2	331	43%	10%	47
Cuschieri et al[60,65]	1996	Europe	D1	200	28%	6.5%	35
			D2	200	46%	13%	33
Wu et al[63,64]	2004	Taiwan	D1	110	7.3%	0%	53.6
			D3	111	17.1%	0%	59.5
Sasako et al[69]	2008	Japan	D2	263	20.9%	0.8%	69.2
			D2 + PAND	260	28.1%	0.8%	70.3
Degiuli et al[67,68]	2010	Italy	D1	133	12%	3%	66.5
			D2	134	17.9%	2.2%	64.2

PAND: Para-aortic node dissection.