Non-invasive diagnosis of liver fibrosis and cirrhosis

Table 1 Diagnostic accuracy of established serum markers

Test	Parameters	Prognosis	Sensitivity	Specificity	AUROC
APRI	AST, platelet count	Significant fibrosis	81	55	0.77
		Cirrhosis	77	75	0.84
FIB-4	Platelet count, AST, ALT, age	Significant fibrosis	64	68	0.74
		Cirrhosis	90	58	0.87
Fibrotest	Haptoglobin, α2-macroglobulin, apolipoprotein A1, γGT, bilirubin	Significant fibrosis	92	38	0.79
		Cirrhosis	83	76	0.86
Forns Index	Age, platelet count, γGT, cholesterol	Significant fibrosis	88	52	0.76
		Cirrhosis	98	27	0.87
HA	hyaluronan	Significant fibrosis	-	-	0.75
		Cirrhosis1	65	86	0.92
HepaScore	Bilirubin, γGT, hyaluronan, α2-macroglobulin, age, gender	Significant fibrosis	66	79	0.79
		Cirrhosis	72	86	0.89
Fibrometer	Platelet count, prothrombin index, AST, α2-macro-globulin, hyaluronan, urea, age	Significant fibrosis	69	81	0.82
		Cirrhosis1	62	87	0.90

¹All values are medians. Except for these values, which were taken from Ref. [11], all other values are from Ref. [42]. APRI: AST to platelet ratio index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase, γGT: γ-glutamyltransferase.

Table 2 Diagnostic accuracy of selected experimental serum markers

Marker	Prognosis	Sensitivity	Specificity	AUROC
PIIINP	Significant fibrosis	74	75	0.72
	Cirrhosis	64	66	0.76
PINP	Significant fibrosis	70	73	-
	Cirrhosis	63	73	-
YKL-40	Significant fibrosis	78	81	0.81
	Cirrhosis	80	71	0.80
TIMP	Significant fibrosis	66	72	0.71
	Cirrhosis	91	65	0.90
sH2a + ALT1	Significant fibrosis	65	85	0.79
	Advanced fibrosis and cirrhosis	-	-	0.86

¹Except for these values, which were taken from Ref. [87], all other values are medians from Ref. [11]. PIIINP: N-terminal pro-peptide of collagen type III; PINP: N-terminal propeptide of collagen type I; TIMP: Tissue inhibitor of metalloproteinase; sH2a: Soluble H2a; ALT: Alanine aminotransferase.