Ultrasound-based elastography for the diagnosis of portal hypertension in cirrhotics

Table 1 Predictive value of transient elastography in the liver for clinically significant portal hypertension

Study	HPVG ≥ 10 mmHg				HVPG ≥ 12 mmHg
	Cut-off (kPa)	AUROC	Se	Sp	Cut-off (kPa)	AUROC	Se	Sp
Vizzutti et al[30], Hepatology 2007	13.6	0.990	97%	92%	17.6	0.92	94.0%	81.0%
Bureau et al[31], Aliment Pharmacol Ther 2008	21	0.945	89.9%	93.2%	-	-	-	-
Reiberger et al[34], Wien Klin Wochenschr 2012	18	0.871	83.4%	82.2%	20.0	0.79	84.2%	80.7%
Salzl et al[35], Ultraschall Med 2014	16.8	0.870	89.7%	75%	-	-	-	-
1Shi et al[46], Liver Int 2013	-	0.930	90%	79%	-	-	-	-

¹Meta-analysis: HSROC and summary Se and summary Sp are presented. HPVG: Hepatic venous pressure gradient; Se: Sensitivity; Sp: Specificity; AUROC: Area under the receiver operating characteristics curve.

Table 2 Predictive value of Transient Elastography in the liver for esophageal varices

Study	At least grade 1 EV				At least grade 2 EV
	Cut-off (kPa)	AUROC	Se	Sp	Cut-off (kPa)	AUROC	Se	Sp
Nguyen-Khac et al[39] Alcohol Clin Exp Res 2010	-	-	-	-	47.2 (alcoholic)	0.770	84.6%	63.6%
Nguyen-Khac et al[39] Alcohol Clin Exp Res 2010	-	-	-	-	19.8 (viral)	0.730	88.9%	55.1%
Sporea et al[40] Med Ultrason 2013	-	-	-	-	32.5 (alcoholic)	0.836	85%	74.6%
Sporea et al[40] Med Ultrason 2013	-	-	-	-	24.8 (viral)	0.867	81%	80.7%
Castéra et al[41] J Hepatol 2009	21.5 (HCV)	0.84	76%	78%	30.5 (HCV)	0.870	77%	85%
Sporea et al[45] World J Gastroenterol 2011	31	0.78	83%	62%	-	-	-	-
1Shi et al[46] Liver Int 2013	-	0.84	87%	53%	-	0.780	0.86%	0.59%

¹Meta-analysis: HSROC and summary Se and summary Sp are presented. EV: Esophageal varices; Se: Sensitivity; Sp: Specificity; AUROC: Area under the receiver operating characteristics curve.

Table 3 Predictive value of acoustic radiation force impulse elastography in the liver for esophageal varices

Study	At least grade 1 EV				At least grade 2 EV
	Cut-off (m/s)	AUROC	Se	Sp	Cut-off (m/s)	AUROC	Se	Sp
Bota et al[67], Ann Hepatol 2012	-	-	-	-	2.25	0.596	93.4%	28.9%
Morishita et al[69], J Gastroenterol 2014	2.05	0.89	83%	76%	2.39	0.868	81.0%	82.0%

EV: Esophageal varices; Se: Sensitivity; Sp: Specificity; AUROC: Area under the receiver operating characteristics curve.