Retrospective Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Oct 21, 2015; 21(39): 11160-11167
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.11160
Table 1 Risk factors for lymph node metastasis in early gastric cancer (n = 2270) by multivariate analysis
OR95%CIP value
Tumor size ≤ 30 mm vs > 30 mm2.11.5-3.0< 0.001
Depth of invasion
M vs SM11.61.0-2.4< 0.001
M vs SM24.73.0-7.20.040
Lymphatic invasion4.12.8-6.0< 0.001
Vascular invasion4.73.1-7.1< 0.001
Table 2 Risk factors for lymph node metastasis in intramucosal gastric cancer (n = 1340) by univariate analysis n (%)
NegativePositiveP value
Gender0.217
Male/female843/45829/10
Age58.5 ± 11.850.6 ± 14.5< 0.001
Size of tumor (mm, mean ± SD)23.5 ± 15.737.9 ± 28.6< 0.001
Tumor size< 0.001
≤ 30 mm961 (81)18 (54)
> 30 mm224 (19)15 (46)
Tumor location0.052
Upper192 (15)14 (36)
Middle736 (59)19 (48)
Lower324 (26)6 (16)
Lauren< 0.001
Intestine type634 (61)11 (38)
Diffuse type371 (36)16 (55)
Mix type33 (3)2 (7)
Histologic type0.715
Differentiated799 (62)20 (53)
Undifferentiated498 (38)18 (47)
Ulcer finding0.757
Absence/presence619/55014/14
Lymphatic invasion< 0.001
Absence/presence1202/9323/15
Vascular invasion< 0.001
Absence/presence1272/2222/17
Perineural invasion< 0.001
Absence/presence1279/1336/3
Table 3 Risk factors for lymph node metastasis in submucosal gastric cancer (n = 930) by univariate analysis n (%)
NegativePositiveP value
Gender0.369
Male/female497/254119/60
Age61.0 ± 11.360.2 ± 11.4< 0.001
Size of tumor (mm, mean ± SD)27.0 ± 14.836.1 ± 19.9< 0.001
Tumor size< 0.001
≤ 20 mm512 (73)94 (55)
> 20 mm188 (27)76 (45)
Tumor location0.651
Upper157 (21)34 (20)
Middle376 (50)93 (52)
Lower223 (29)52 (28)
Lauren0.514
Intestine type343 (56)69 (47)
Diffuse type215 (35)63 (43)
Mix type52 (9)16 (10)
Histologic type0.884
Differentiated489 (65)113 (63)
Undifferentiated258 (35)66 (37)
Ulcer finding0.115
Absence/presence255/38851/104
Lymphatic invasion< 0.001
Absence/presence526/22247/130
Vascular invasion< 0.001
Absence/presence665/82104/71
Perineural invasion0.103
Absence/presence693/56157/22
Table 4 Lymph node metastasis according to the presence of ulcer, differentiation, lymphovascular invasion, and the depth of invasion in early gastric cancer patients
UlcerDifferentiationVILISize
10 mm> 10 mm> 20 mm> 30 mm
M
Ulcer negativeDifferentiatedNoNo0/1022/1120/811/57
Yes0/50/20/10/5
YesNo0001/2
Yes01/20/01/2
UndifferentiatedNoNo1/662/410/411/45
Yes0/30/30/10/2
YesNo0000
Yes000/13/3
Ulcer positiveDifferentiatedNoNo1/591/1040/671/47
Yes0/51/120/11/5
YesNo0000
Yes0/20/40/01/1
UndifferentiatedNoNo0/400/501/420/46
Yes0/40/20/61/4
YesNo0000
Yes0/11/20/11/1
SM1
Ulcer negativeDifferentiatedNoNo0/101/190/121/13
Yes0/30/31/20/1
YesNo001/12/2
Yes01/30/01/3
UndifferentiatedNoNo0/70/61/80/6
Yes00/20/00/1
YesNo0000
Yes00/10/12/3
Ulcer positiveDifferentiatedNoNo0/142/240/191/13
Yes0/10/01/71/5
YesNo00/10/00
Yes00/12/33/3
UndifferentiatedNoNo0/62/122/71/6
Yes0/21/70/31/7
YesNo0001/1
Yes1/23/51/41/1
SM2
Ulcer negativeDifferentiatedNoNo0/42/231/250/18
Yes01/122/511/27
YesNo0/10/00/00
Yes0/11/30/16/8
UndifferentiatedNoNo0/11/142/91/4
Yes0/21/10/23/7
YesNo0/10/00/00
Yes0/10/05/61/3
Ulcer positiveDifferentiatedNoNo3/162/331/313/31
Yes0/35/1512/2713/31
YesNo001/30/3
Yes0/11/22/54/5
UndifferentiatedNoNo0/42/141/194/18
Yes0/21/81/64/11
YesNo000/11/1
Yes1/13/45/83/5