Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy

Table 1 Overview of the studies that were included for the analysis

Study	Patients	Study aim
Registry analysis[24]	551	Technical and clinical feasibility
	(488 TVC)	Safety (particularly regarding access related complications)
Cohort study A[25]	100	Benefit (postoperative pain)
(Early postoperatively)	(50 TVC; 50 LC)	Disadvantages (specific complications)
Cohort study B[26]	881	Long-term problems (particularly regarding sexual intercourse)
(24 mo postoperatively)	(46 TVC; 42 LC)	Patient satisfaction
NATCH-study[29]	40	Benefit (postoperative pain)
(Early postoperatively)	(20 TVC; 20 NC)	Disadvantages (specific complications)
NATCH-study[30]	40	Long-term problems (particularly regarding sexual intercourse)
(3 and 6 mo postoperatively)	(20 TVC; 20 NC)	Patient satisfaction

¹From the collective of cohort study A. TVC: Transvaginal cholecystectomy; LC: Traditional laparoscopic cholecystectomy; NC: Needlescopic 3-trocar-cholecystectomy.