Systematic Reviews
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 28, 2015; 21(28): 8678-8686
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8678
Table 1 Analytical studies on pancreatic cancer screening
StudyType of study (number of subjects)CountryDuration of follow-upMeasured outcome
Canto et al[12], 2006Prospective controlled studyAbout 3 yrDifferent diagnostic rate of PC, tumor type and screening complications
(n = 227)United States
Kim et al[13], 2011RetrospectiveDifferent tumor type, curative resection, median survival, 3-yr survival rate
controlled studyKorea-
(n = 60)
Potjer et al[14], 2013Prospective controlled studyA minimum of 1 yrDifferent tumor type, frequency and behavior of precursor lesions
(n = 241)Netherland
Lachter et al[15], 2007RetrospectiveDifferent diagnostic rate of PC, the number of operations
controlled studyIsrael-
(n = 134)
Zubarik et al[16], 2011Prospective controlled studyDifferent diagnostic rate of PC, tumor type, screening complications and cost of detection
(n = 670)United States1 yr
Table 2 Non-controlled studies on pancreatic cancer screening
Study (author/year)CountryStudy population n (HRIs%)Period of timePancreatic tumor, n (%)PC/death, n (%)
Langer et al[17], 2009Germany76 (100)5 yr6 (7.9)0 (0)/0 (0)
Rulyak et al[18], 2001United States35 (100)2 yr12 (34.3)0 (0)/0 (0)
Sud et al[19], 2014United States30 (63.3)3 yr3 (10)2 (6.7)/0 (0)
Al-Sukhni et al[20], 2012Canada262 (60.9)8 yr84 (32.1)3 (1.1)/2 (0.8%)
Verna et al[21], 2010United States51 (100)3 yr20 (39.2)2 (3.9)/0 (0)
Poley et al[22], 2009Netherland44 (47.7)2 yr10 (22.7)3 (6.8)/2 (4.5)
Ludwig et al[23], 2011United States109 (100)7 yr9 (8.3)1 (0.9)/0 (0)
Brentnall et al[24], 1999United States14 (100)15 mo7 (50)0 (0)/0 (0)
Canto et al[25], 2012United States216 (90)28.8 mo92 (45.6)0 (0)/0 (0)
Table 3 Studies on precursor lesions
CategorySurgery, nFollow-up, nComplications and prognosis
PanIN170Just one patient had a fistula after surgery
IPMN1197No relapse or canceration after surgery or follow-up
IPMN + PanIN60No relapse or canceration after surgery
Mass lesions30One patient died after surgery; two patients relapsed then treated with chemotherapy
Cytological HGD70No relapse or canceration after surgery; one patient had hemorrhage 13 mo later
Table 4 Prospective studies on psychological function
StudyCountryType of study (number of subjects)Result
Maheu et al[29], 2010CanadaProspective controlled study (n = 198)Non-significant increase in risk perception, cancer worry, or general distress
Breitkopf et al[30], 2012United StatesProspective controlled study (n = 1406)HRIs had a greater perceived risk of PC and higher levels of PC worry than controls