Retrospective Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 28, 2015; 21(28): 8636-8643
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8636
Table 1 Clinical characteristics and outcomes of patients with peptic ulcer bleeding
Etiology of PUBIdiopathic (n = 20)H. pylori-associated (n = 108)Drug-induced (n = 74)Combined (H. pylori, Drug) (n = 30)P valueP value1P value2P value3
Age55.15 ± 12.3347.83 ± 15.1568.49 ± 14.7663.87 ± 14.79< 0.010.09< 0.010.09
Sex (M:F)19:189:1937:3717:13< 0.010.24< 0.01< 0.01
Smoking (Yes:No)10:1053:5521:537:23< 0.0110.120.10
Alcohol (Yes:No)6:1427:8114:605:250.5540.850.3640.314
Gastric ulcer (GU)12535721< 0.010.6440.0440.084
Duodenal ulcer (DU)64462
GU + DU211117
Initial hemoglobin (g/dL)9.98 ± 3.159.36 ± 2.568.75 ± 2.738.84 ± 2.390.190.570.140.26
Creatinine (mg/dL)1.040 ± 0.1791.018 ± 0.4351.255 ± 0.8451.03 ± 0.3560.050.990.271.00
Duration of admission (d)6.15 ± 2.2775.602 ± 2.4118.473 ± 8.9195.5 ± 2.556< 0.010.930.180.93
Ulcer size (cm)1.21 ± 0.650.86 ± 0.511.25 ± 0.921.07 ± 0.80< 0.010.120.990.80
Needs for transfusion(PRC no.)2.35 ± 2.462.21 ± 1.983.53 ± 4.942.53 ± 1.740.060.990.290.99
Re-bleeding caseupon admission:6822< 0.014< 0.014< 0.014< 0.054
Re-admission23420.3040.1740.60414
Past history of ulcer62528< 0.0140.574< 0.0141
Blatchford score8.85 ± 4.068.56 ± 3.719.78 ± 3.7710.40 ± 3.940.050.970.560.29
Rockall score3.50 ± 1.053.05 ± 1.544.73 ± 2.214.73 ± 1.87< 0.010.520.020.04
Table 2 Univariate and multivariate analysis between idiopathic and Helicobacter pylori-associated peptic ulcer bleeding
Idiopathic PUB (n = 20)Helicobacter pylori-associated PUB (n = 108)P value1OR (95%CI)1P value2OR (95%CI)2
Age0.711.224 (0.43-3.49)0.941.04 (0.34-3.18)
≥ 60 yr628
< 60 yr1480
Ulcer size0.062.55 (0.96-6.77)0.152.13 (0.76-5.95)
≥ 1.0 cm1240
< 1.0 cm868
Re-bleeding case upon admission
Yes68< 0.015.36 (1.62-17.74)0.024.56 (1.34-15.54)
No14100
Table 3 Univariate and multivariate analysis between idiopathic and drug-induced peptic ulcer bleeding
Idiopathic PUB (n = 20)Drug-induced PUB (n = 74)P value1OR (95%CI)1P value2OR (95%CI)2
Age< 0.010.16 (0.05-0.47)< 0.010.12 (0.03-0.55)
≥ 60 yr654
< 60 yr1420
Sex< 0.0119.00 (2.42-149.36)0.068.59 (0.94-83.82)
Male1937
Female137
Ulcer type0.024.86 (1.37-17.29)0.083.86 (0.85-17.55)
Duodenal ulcer66
Others1468
Ulcer size0.601.31 (0.48-3.58)0.162.65 (0.68-10.29)
≥ 1.0 cm1239
< 1.0 cm835
Re-bleeding case upon admission
Yes62< 0.0115.43 (2.82-84.43)< 0.0119.76 (2.39-162.91)
No1472
Table 4 Univariate and multivariate analysis between drug-induced and Helicobacter pylori-associated peptic ulcer bleeding
Drug-induced PUB (n = 74)Helicobacter pylori-associated PUB (n = 108)P value1OR (95%CI)1P value2OR (95%CI)2
Age< 0.017.71 (3.95-15.07)< 0.014.51 (1.83-11.11)
≥ 60 yr5428
< 60 yr2080
Sex< 0.010.21 (0.11-0.42)0.030.39 (0.17-0.91)
Male3789
Female3719
Ulcer type< 0.013.48 (1.80-6.73)< 0.014.09 (1.73-9.64)
Gastric ulcer5753
Others1755
Ulcer size0.031.95 (1.07-3.57)0.620.82 (0.37-1.81)
≥ 1.0 cm3940
< 1.0 cm3568
Creatinine0.610.85 (0.47-1.55)0.110.52 (0.23-1.16)
≥ 1.0 mg/dL4164
< 1.0 mg/dL3344
Duration of admission< 0.012.71 (1.45-5.07)0.042.28 (1.04-5.00)
≥ 7 d3628
< 7 d3880
Needs for transfusion0.431.28 (0.70-2.34)0.621.23 (0.55-2.76)
≥ 3 PRCs3139
< 3 PRCs4369
Blatchford score0.022.15 (1.16-3.96)0.21.70 (0.76-3.82)
≥ 10 points4851
< 10 points2657
Rockall score< 0.013.94 (2.09-7.43)0.491.35 (0.58-3.13)
≥ 4 points5140
< 4 points2368