Case Report
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jun 21, 2015; 21(23): 7335-7342
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7335
Table 1 Summary of reported cases of liver carcinosarcoma with combined hepatocellular cholangiocarcinoma
Ref.Age (yr)SexPositive tumor markerHBVHCVCirrhosisSize (cm)Sarcoma elementTreatmentMetastasisOutcome
Nakajima et al[2]74M--NAPrecirrhotic fibrosis15 × 13Pleomorphic cells, spindle shaped cells, and osteoplastic cellsMitomycin CLiver, lung, lymph nodes, stomach, peritoneumDied within 5 mo
Papotti et al[3]59M----4.0 × 5.2Spindle cellsRight hepatectomyPVTTDied within 4 mo
Goto et al[1]73MAFP+NA+3 × 2.5 × 2Chondrosarcoma, osteosarcomaSegmentectomy-19 mo, alive
CEA
CA19-9
DCP
Present case45MAFP+-+7 × 5Chondrosarcoma, osteosarcoma, spindle cells, and bizarre cellsSegmentectomyDiaphragm7 mo, alive
CA 12-5
Table 2 Results of immunohistochemistry
MarkerCarcinomatous componentSarcomatouscomponent
EMA+++
CK19++-
CK8/18++-
Hepatocyte++-
Pan-CK++-
Galectin-3++
CD117++
VIM-++
SMA-++
S-100-+
DES--
Ki-67+++