Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2015; 21(23): 7335-7342
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7335
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7335
Primary combined hepatocellular-cholangiocellular sarcoma: An unusual case
Shuai Xiang, Yi-Fa Chen, Yan Guan, Xiao-Ping Chen, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Xiang S, Chen YF and Chen XP performed the operation; Guan Y performed histologic experiments; Xiang S and Chen XP wrote the paper; Chen XP critically revised the paper.
Supported by Grants from the Hepatic Surgery Clinical Study Center of Hubei Province, China, No. 2014BKB089.
Ethics approval: The study was reviewed and approved by the Institutional Review Board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology.
Informed consent: The patient and his wife provided informed written consent prior to study enrollment.
Conflict-of-interest: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiao-Ping Chen, MD, PhD, FACS, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefangdadao, Wuhan 430030, Hubei Province, China. chenxpchenxp@163.com
Telephone: +86-27-83663500 Fax: +86-27-83663500
Received: November 12, 2014
Peer-review started: November 15, 2014
First decision: January 22, 2015
Revised: February 10, 2015
Accepted: April 3, 2015
Article in press: April 3, 2015
Published online: June 21, 2015
Peer-review started: November 15, 2014
First decision: January 22, 2015
Revised: February 10, 2015
Accepted: April 3, 2015
Article in press: April 3, 2015
Published online: June 21, 2015
Core Tip
Core tip: Primary mixed-type hepatocellular-cholangiocellular sarcoma is extremely rare. The histogenetic origin of this tumor is controversial. We report a case with special characteristics and propose a new hypothesis combining stem cell theory and “conversion” theory, which may be more appropriately applied to this case.