3.0T 1H magnetic resonance spectroscopy for assessment of steatosis in patients with chronic hepatitis C

Table 1 Patient demographics and baseline characteristics

	No fatty liver (n = 30)	Mild fatty liver (n = 26)	Moderate fatty liver (n = 16)	Severe fatty liver (n = 9)
Age (yr)	49.8 ± 10.6	53.4 ± 9.8	52.7 ± 10.4	55.6 ± 11.2
Gender	Male 8 (53.33%)	Male 6 (46.15%)	Male 5 (62.5%)a	Male 7 (77.78%)a
HCV-RNA(copies/mL)	5.18 ± 1.20	5.43 ± 1.14	5.23 ± 1.65	5.43 ± 1.47
Child-Plug	3 ± 1	4 ± 1	6 ± 1	7 ± 1
TBIL	12.7 ± 6.7	13.9 ± 6.4	26.6 ± 6.9a	38.7 ± 11.6a
ALT	12.9 ± 10.6	18.8 ± 12.3	62.4 ± 13.2a	103.8 ± 20.3a
AST	10.7 ± 9.9	16.5 ± 10.1	52.5 ± 12.3a	87.7 ± 16.2a
TG	1.2 ± 0.3	1.8 ± 0.4	3.2 ± 1.1a	5.4 ± 2.1a
Chol	2.7 ± 1.2	3.3 ± 1.5	5.4 ± 1.8a	6.7 ± 2.2a
Blood glucose	4.1 ± 0.2	4.3 ± 0.3	5.8 ± 2.0a	7.4 ± 3.3a

^aP < 0.05, vs no fatty liver group and mild fatty liver group.

Table 2 ¹H magnetic resonance spectroscopy spectrum parameters for different fatty liver pathological levels

Group	Peak of fat	Fat area under the peak	Peak of water	Water area under the peak	Fat/water peak ratio	Fat/water under the peak area ratio
No fatty liver	81.4 ± 46.1	32.56 ± 18.44	1450 ± 540	575.9 ± 216.4	0.0789 ± 0.0612	0.0846 ± 0.0531
Mild fatty liver	181.5 ± 87.7	71.87 ± 35.14	1340 ± 590	528.4 ± 223.8	0.2038 ± 0.1552	0.2124 ± 0.1588
Moderate fatty liver	596.4 ± 293.8a	238.6 ± 117.5a	1460 ± 670	582.6 ± 247.9	0.6344 ± 0.4924a	0.5968 ± 0.4326a
Severe fatty liver	1155.6 ± 250.2a	462.2 ± 120.16a	1420 ± 480	568.7 ± 197.2	0.8856 ± 0.4795a	0.8742 ± 0.4528a

^aP < 0.05, vs no fatty liver group and mild fatty liver group.