Different treatment strategies and molecular features between right-sided and left-sided colon cancers

Table 1 Differences regarding survival, treatment, and molecular levels between right and left colon cancer.

	RCC	LCC
Survival
5-yr OS in 1990s	56.3%	59.7%	P < 0.01
in 2000s	67%	71%	P < 0.01
5-yr DFS in 2010	73%	74%	P > 0.05
in 2014	88.6%	89.4%	P > 0.05
Median OS (mo)	18.2%	29.4%	P < 0.001
Dominant treatment - Adjuvant	FOLFIRI	FOLFOX
Palliative	Anti-EGFR therapy	Anti-angiogenesis
Molecular levels
Carcinogenesis mechanisms	MMR, KRAS, BRAF, miRNA-31	CIN (p53), NRAS; miRNA-146a, 147b, 1288
Protein expressions	GNAS, NQO1, Telomerase, p-PDH	ANXA10, Topo I,
		TS, EGFR
Relapse pathways	Cell cycle control genes, high WNT signaling	Stromal expression, low WNT signaling
Prognostic biomarkers	CDX2, ITGA3	NOX4

RCC: Right colon cancer; LCC: Left colon cancer.