miRNA-103: Molecular link between insulin resistance and nonalcoholic fatty liver disease

Table 1 Clinical characteristics of the study subjects (mean ± SD)

	NAFLD group (n = 50)	Normal control group (n = 30)
Age (yr)	50 ± 6.70	50 ± 6.81
Gender (male/female)	28/22	16/14
BMI (kg/m2)	28.70 ± 3.12b	22.80 ± 3.07
ln (HOMA-IR)	1.72 ± 0.35b	0.38 ± 0.31
Fins (IU/mL)	16.3 ± 3.06b	8.55 ± 3.21
TG (mmol/L)	2.67 ± 1.23b	1.58 ± 1.19
TC (mmol/L)	5.01 ± 0.89a	4.61 ± 0.97
FPG (mmol/L)	5.95 ± 0.93b	4.85 ± 0.87
ALT (U/L)	38.10 ± 19.80b	26.30 ± 20.14

^aP < 0.05,

^bP < 0.01 vs the control group (unpaired Student t test and χ² test). NAFLD: Nonalcoholic fatty liver disease; BMI: Body mass index; Fins: Fasting insulin; ln (HOMA-IR): Homeostasis model assessment-insulin resistance was log-transformed before analysis as it was not normally distributed; FPG: Fasting plasma glucose; TC: Total cholesterol; TG: Triglycerides; ALT: Alanine transaminase.

Table 2 Linear regression analysis of factors affecting homeostasis model assessment-insulin resistance

	Independent variables	Independent variables	SE standard regression	t value	P value
BMI	0.251	0.072	0.431	3.510	0.001
miR-103	0.438	0.113	0.302	3.890	0.000
TG	0.657	0.236	0.258	2.779	0.007

BMI: Body mass index; miR-103: MicroRNA-103; TG: Triglyceride; HOMA-IR: Homeostasis model assessment-insulin resistance.

Table 3 Binary logistic regression analysis of factors affecting nonalcoholic fatty liver disease

Variables	P value	OR	95%CI
miR-103	0.009	2.411	1.25-4.652
TG	0.022	16.196	1.507-174.013
BMI	0.010	1.574	1.117-20.219
HOMA-IR	0.014	19.11	1.808-202.001

BMI: Body mass index; miR-103: MicroRNA-103; TG: Triglyceride; HOMA-IR: Homeostasis model assessment-insulin resistance.