Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.511
Peer-review started: May 12, 2014
First decision: June 18, 2014
Revised: June 20, 2014
Accepted: July 30, 2014
Article in press: July 30, 2014
Published online: January 14, 2015
Core tip: Insulin resistance activates development of nonalcoholic fatty liver disease (NAFLD), however, the molecular mechanism is not fully understood. We determined fasting plasma glucose, fasting insulin, triglyceride (TG) and the levels of miRNA-103 (miR-103) in the serum of patients with NAFLD. We found that higher levels of miR-103 were expressed in the serum of patients with NAFLD. miR-103 was positively correlated with homeostasis model assessment and was used to evaluate basal insulin resistance (HOMA-IR), TG and BMI, respectively. miR-103 was an independent factor for HOMA-IR and a risk factor for NAFLD. We conclude that miR-103 is involved in insulin resistance and NAFLD.