Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA

Table 1 Normalized signal intensity and mean enhancement ratio of the pancreas in the diabetic rat group (n = 6) and the control rat (n = 5) group

	Pre	Imm after Gd-DOTA	3 min after Gd-DOTA	Imm after GdP	30 min after GdP	24 h after GdP
Normalized signal intensity of the pancreas
Control rats	137.9 (132.0, 152.4)	165.6 (160.0, 177.8)	158.2 (141.2, 161.3)	238.4 (201.8, 311.6)	264.7 (212.5, 280.7)b	171.0 (147.3, 178.9)
Diabetic rats	146.6 (135.2, 161.7)	184.4 (164.0, 218.7)	173.3 (153.2, 185.9)	277.1 (217.0, 317.4)	302.6 (295.6, 353.3)b	177.9 (145.9, 189.7)
Enhancement ratio of the pancreas (%)
Control rats		20.5 (8.7, 27.9)	9.3 (-7.3, 21.6)	80.8 (46.3, 111.2)	79.5 (54.1, 101.6)a	17.4 (11.6, 24.0)
Diabetic rats		29.3 (11.8, 45.5)	14.8 (4.9, 34.4)	79.3 (47.5, 129.3)	103.3 (87.9, 151.1)a	16.5 (-0.1, 34.8)

Data are shown as the median (lowest value, highest value). P values were calculated using the Mann-Whitney test. Imm: immediate; GdP: Gadofluorine P.

^aP < 0.05 control rats vs diabetic rats;

^bP < 0.01 control rats vs diabetic rats.

Table 2 Area under the receiver operating characteristics curve for Gadofluorine P and Gd-DOTA for differentiating diabetic rats from the control group

	AUC
Enhancement ratio 3 min after Gd-DOTA	0.667 (0.334-0.908)
Enhancement ratio 30 min after GdP	0.967 (0.664-1.000)

Numbers in parentheses indicates the 95%CI. AUC: Area under the receiver operating characteristics curve; GdP: Gadofluorine P.