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Copyright ©The Author(s) 2015.
World J Gastroenterol. May 21, 2015; 21(19): 5823-5830
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5823
Table 1 Main characteristics of CD4 T-cell subsets
CD4 T-cell subsetsSurface expressionPolarizing CytokinesMaster regulator transcription factorSTAT regulatorsEffector profile/signature cytokines
Th1IL-12RB2IL-12,STAT1,IFN-γ,
IFN-γRIFN-γ,T-betSTAT4IL-2,
Tim3IL-27TNF-α,
IL-10
Th2IL-17RBIL-4,
Tim1IL-25,GATA-3STAT6IL-4, IL-5,
IL-6MAFIL-13, IL-25,
IL-2, IL-10
Th17IL-1R1TGF-β,RORγt,IL-17A,
IL-12RBIL-6,RORα,IL-17F,
IL-23RIL-1β,STAT3Il-21,
CCR6IL-21,IL-22
CD161IL-23
IL-13Ra1
TREGCD25
CD39TGF-βFoxp3STAT5TGF-β,
CD73IL-10
CD101
CD127
TFhCD84IL-6,Bcl6IL-6,
CXCR5IL-1β, TNFαIRF4,IL-2,
IL-6RIL-21c-Maf,STAT3/5IL-10,
IL-21RCXCL13Batf,IL-21
gp130