Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection

doi:10.3748/wjg.v21.i18.5496

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 18

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7447)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

339

WORD

236

HTML

2920

Figures (1-2)

196

Tables (1-2)

131

Sum=3822

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

549

Download

941

Sum=1490

Publishing Process of This Article

Item

Count

Browse

885

Download

1250

Sum=2135

May 14, 2015 (publication date) through Apr 24, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. May 14, 2015; 21(18): 5496-5504
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5496

Table 1 Clinical and laboratory characteristics of patients n (%)

	ESRD	Controls	P value
	(n = 39)	(n = 109)
Age, median (range)	52 (25-69)	46 (17-67)	0.013
Gender, F/M	15/24 (38.5/61.5)	55/54 (50.5/49.5)	0.262
Fibrosis stage before treatment according to Metavir score
F0	2 (5.1)	3 (2.8)	0.072
F1	12 (30.8)	25 (22.9)
F2	6 (15.4)	21 (19.3)
F3	1 (2.6)	21 (19.3)
F4	8 (20.5)	31 (28.4)
F unknown	10 (25.6)	8 (7.3)
BMI, average (mean ± SD)	24 ± 4.1	25 ± 4.0	0.071
Type 2 diabetes	5 (12.8)	12 (11.0)	0.773
Initial ALT (IU/L), average (mean ± SD)	57 ± 54	105 ± 87	< 0.001
Initial viral load (IU/mL x 1000), median (IQR)	193 (16-810)	541 (163-1853)	0.003
RVR	20 (52.6)	39 (36.1)	0.074
EVR	29 (74.4)	60 (55.0)	0.038
SVR	25 (64.1)	55 (50.5)	0.190
Premature termination of treatment	14 (35.9)	44 (40.4)	0.704
IL28B CC genotype	11 (28.2)	21 (19.3)	0.262
IFNL4 TT genotype	11 (28.9)	21 (19.3)	0.370
Initial viral load < 600000 IU/mL	28 (71.8)	51 (46.8)	0.009
History of kidney transplant	29 (74.4)	NA	NA
Concurrent treatment with ribavirin	23 (59.0)	109 (100.0)	< 0.001

Controls: HCV patients with normal pretreatment renal function; ESRD: HCV patients with end-stage renal disease treated with haemodialysis; BMI: Body mass index; RVR: Rapid virological response; EVR: Early virological response; SVR: Sustained virological response; HCV: Hepatitis C virus; NA: Not applicable.

Table 2 Initial viral load and IL28B rs12979860 genotype in patients grouped according to their sustained virological response achievement n (%)

Patients	SVR	IVL (IU/mL)	IL28B rs12979860 genotype
Patients	SVR	IVL (IU/mL)	CT or TT	CC
ESRD	Yes	< 600000	14 (58)	10 (42)
	Yes	> 600000	0 (0)	1 (100)
	No	< 600000	4 (100)	0 (0)
	No	> 600000	10 (100)	0 (0)
controls	Yes	< 600000	26 (84)	5 (16)
	Yes	> 600000	10 (42)	14 (58)¹
	No	< 600000	18 (90)	2 (10)
	No	> 600000	33 (97)	1 (3)

¹Includes the patient with IL28B CT and IFNL4 TT/TT. IVL: Initial viral load; ESRD: End-stage renal disease; SVR: Sustained virological response.

Citation: Sperl J, Frankova S, Senkerikova R, Neroldova M, Hejda V, Volfova M, Merta D, Viklicky O, Spicak J, Jirsa M. Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection. World J Gastroenterol 2015; 21(18): 5496-5504
URL: https://www.wjgnet.com/1007-9327/full/v21/i18/5496.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i18.5496