Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19+ cells in Crohn’s disease

Table 1 Anti-Epstein-Barr virus IgG antibodies according to treatment in Crohn’s disease patients n (%)

Treatment type	Treated	Anti-EBV IgG	Untreated	Anti-EBV IgG	P value
All drugs	21 (58.3)	131.5 ± 46.2	15 (41.7)	95.4 ± 53.9	0.038
Azathioprine	8 (22.2)	122.4 ± 45.8	28 (77.8)	114.7 ± 54.3	0.720
Anti-TNF	3 (8.3)	106.0 ± 67.4	33 (91.7)	117.4 ± 51.7	0.722
5-ASA	12 (33.3)	144.3 ± 47.7	24 (66.7)	102.6 ± 49.3	0.010
Antibiotic	5 (13.9)	87.6 ± 45.3	31 (86.1)	121.1 ± 52.2	0.161
Corticosteroids	6 (16.7)	105.2 ± 45.7	30 (83.3)	118.7 ± 53.7	0.538
Drugs/patient
0	21 (100)	95.4 ± 53.9
1	10 (47.6)	146.5 ± 36.3	15 (41.7)	95.4 ± 53.9	0.023
2	8 (38.1)	132.1 ± 46.2	15 (41.7)	95.4 ± 53.9	0.169
3	3 (14.3)a	80.0 ± 53.5	15 (41.7)	95.4 ± 53.9	0.824

Values are expressed as mean ± SD.

^aP < 0.05 vs 1 drug/patient. 5-ASA: 5-Aminosalicylic acid; TNF: Tumor necrosis factor.