Observational Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 21, 2015; 21(15): 4666-4672
Published online Apr 21, 2015. doi: 10.3748/wjg.v21.i15.4666
Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19+ cells in Crohn’s disease
Juan C Andreu-Ballester, Rafael Gil-Borrás, Carlos García-Ballesteros, Ignacio Catalán-Serra, Victoria Amigo, Virgina Fernández-Fígares, Carmen Cuéllar
Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain
Rafael Gil-Borrás, Ignacio Catalán-Serra, Digestive Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain
Carlos García-Ballesteros, Victoria Amigo, Hematology Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain
Virgina Fernández-Fígares, Carmen Cuéllar, Department of Parasitology, Faculty of Pharmacy, Complutense University, 28040 Madrid, Spain
Author contributions: Cuéllar C and Andreu-Ballester JC were involved with conception and design of the study; Gil-Borrás R and Catalán-Serra I contributed to acquisition of data and patients; Cuéllar C and Fernández-Fígares V were involved with determination of IgG antibodies against Epstein-Barr virus; Amigo V and García-Ballesteros C contributed to flow cytometry analysis; Cuéllar C and Andreu-Ballester JC were involved with analysis and interpretation of data, drafting and revising the article, and final approval of the version to be submitted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Juan C Andreu-Ballester, MD, PhD, Research Department, Arnau de Vilanova Hospital, c/San Clemente 12, 46015 Valencia, Spain. jcandreu@ono.com
Telephone: +34-963-868784 Fax: +34-963-868580
Received: May 20, 2014
Peer-review started: May 21, 2014
First decision: July 8, 2014
Revised: July 24, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: April 21, 2015
Core Tip

Core tip: The prevalence of anti-Epstein-Barr virus (EBV) IgG antibodies was studied in patients with Crohn’s disease. The lowest anti-EBV IgG levels were observed in the patients without specific treatment. 5-aminosalicylic acid treatment showed the highest anti-EBV IgG values. CD19+ cells had the largest decrease in Crohn’s disease patients that had received treatment. Crohn’s disease patients had the highest values of anti-EBV IgG.