Hepatitis C virus and antiviral innate immunity: Who wins at tug-of-war?

doi:10.3748/wjg.v21.i13.3786

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2015; 21(13): 3786-3800
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3786

Table 1 Antiviral interferon-stimulated genes targeting different steps of the hepatitis C virus life cycle

Gene symbol	Phases of HCV life cycle targeted by ISGs	Infection or replicon for studies	Overexpression or knockdown of ISGs for tests	Ref.
IFITM1	Entry	Infection	oe/kd	[158]
	Replication	Infection	oe/kd	[159]
	Replication	Replicon	kd	[147]
IFITM3	Translation	Replicon	oe	[161]
	Replication	Replicon	oe	[160]
	Replication	Replicon	oe/kd	[147]
DDIT4	Translation	Infection/replicon	oe	[144]
IFI44L	Translation	Infection/replicon	oe	[144]
IRF1	Translation	Infection/replicon	oe	[144]
IRF1	Replication	Replicon	oe	[162]
IRF2	Translation	Infection/replicon	oe	[144]
IRF7	Translation	Infection/replicon	oe	[144]
MAP3K14	Translation	Infection/replicon	oe	[144]
MDA5	Translation	Infection/replicon	oe	[144]
NT5C3	Translation	Infection/replicon	oe	[144]
RIG-I	Translation	Infection/replicon	oe	[144]
OASL	Translation	Infection	oe	[144]
OASL	Replication	Replicon	oe	[152]
RNaseL	Replication	Replicon	oe/kd	[147]
RNaseL	Replication	Infection	oe	[153]
ADAR1	Replication	Replicon	kd	[163]
GBP-1	Replication	Replicon	oe/kd	[162]
IFI27	Replication	Replicon	oe/kd	[162]
IFI6	Replication	Replicon	oe/kd	[162]
IFIT1	Replication	Infection	oe/kd	[162]
IFIT3	Replication	Replicon	kd	[147]
IRF9	Replication	Replicon	oe	[162]
ISG20	Replication	Replicon	oe	[164]
MxA	Replication	Replicon	oe	[162]
NOS2	Replication	Replicon	oe/kd	[147]
OAS	Replication	Replicon	oe	[162]
PLSCR1	Replication	Replicon	oe/kd	[147]
TRIM14	Replication	Replicon	oe/kd	[147]
Viperin	Replication	Replicon	oe	[164]
	Replication	Replicon	oe	[165]
	Replication	Infection/replicon	oe	[155]
	Replication	Infection	kd	[156]
Tetherin	Release	Infection	oe	[166]

HCV: Hepatitis C virus; ISGs: Interferon-stimulated genes; Infection or replicon: The functions of ISGs were studied by using infectious culture system (infection) or subgenomic replicon (replicon); oe or kd: The functions of ISGs were identified by using overexpression (oe) or knockdown (kd) of indicated ISGs in cells.

Citation: Yang DR, Zhu HZ. Hepatitis C virus and antiviral innate immunity: Who wins at tug-of-war? World J Gastroenterol 2015; 21(13): 3786-3800
URL: https://www.wjgnet.com/1007-9327/full/v21/i13/3786.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i13.3786