Copyright ©The Author(s) 2015.
World J Gastroenterol. Mar 28, 2015; 21(12): 3480-3491
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3480
Table 1 Summary of published works about hepatitis C virus-specific cytotoxic T lymphocyte during anti-hepatitis C virus treatment pointing-out the data in favor and against hepatitis C virus-specific cytotoxic T lymphocyte response restoration either during or after treatment
Ref.YearTreatmentSamplesCTL visualizationIn favorAgainst
Martin et al[89]2014DAAFrozen PBMCTetramer stainingRestoration of HCV-specific CTL response during treatment in SVR cases
Larrubia et al[60]2013PEG-IFN/RBVFresh PBMCPentamer stainingHCV-CTLs detection at week 12 of treatment correlates with infection resolution Detection of PD-1low HCV-specific CTLs after treatment correlates with SVR
Humphreys et al[82]2012PEG-IFN/RBVFrozen PBMCγ-IFN ELISPOT assayTreatment induced genotype-3a viral clearance is not associated with an enhancement of antiviral T cell response
Tatsumi et al[78]2011PEG-IFN/RBVFresh PBMCγ-IFN ELISPOT assayHCV-specific CTL frequency increase between base-line and treatment week 4 was observed in SVR but not in non SVR patients
Barnes et al[83]2009PEG-IFN/RBVFrozen PBMCγ-IFN and IL-2 ELISPOT assayNot enhanced specific T cell response during high dose IFNa therapy was reported
Caetano et al[77]2008PEG-IFN/RBVFresh PBMCPentamer stainingChronically infected patients who responded to treatment showed a higher HCV-specific CTL frequency than non-responders during and post-treatment Terminally differentiated effector cells increased more rapidly in responders, and their frequency was always higher than in non-responder patients
Golden-Mason et al[85]2008PEG-IFN/RBVPBMCPentamer stainingPatients with sustained viral response showed a decrease in PD-1 expression on HCV-specific CTLs after therapy completion
Badr et al[73]2008PEG-IFNFrozen PBMCTetramer stainingEarly therapeutic intervention during the acute phase of HCV infection reconstituted a long-lived polyfunctional memory T cell response
Pilli et al[81]2007PEG-IFN/RBVFrozen PBMCγIFN ELISPOT assay and tetramer stainingNo significant correlation between HCV-specific CTL kinetics and viral decay during treatment
Morishima et al[75]2003IFN/RBVFresh PBMCChromium-51 release assaySubjects who had completed the treatment and had undetectable HCV RNA levels after therapy had a detectable HCV-specific CTL response more frequently than those who were viraemic
Vertuani et al[76]2002IFNFresh PBMCChromium-51 release assayIncrease in the intensity of HCV epitope recognition by HCV-specific CTL after 1 to 5 m of treatment
Barnes et al[79]2002IFN/RBVFrozen PBMCγIFN ELISPOT assayT cell responses induced during high dose of IFNa treatment appear not to influence the virological outcome